Concomitant induction of SLIT3 and microRNA-218–2 in macrophages by toll-like receptor 4 activation limits osteoclast commitment

Concomitant induction of SLIT3 and microRNA-218–2 in macrophages by toll-like receptor 4 activation limits osteoclast commitment

Abstract Background Toll-like receptor 4 (TLR4) conducts a highly regulated inflammatory process by limiting the extent of inflammation to avoid toxicity and tissue damage, even in bone tissues. Thus, it is plausible that strategies for the maintenance of normal bone-immunity to prevent undesirable...

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Bibliographic Details
Main Authors: Eun-Young Kim, Ji-Eun Kim, Soo-Hyun Chung, Ji-Eun Park, Dohee Yoon, Hyo-Jin Min, Yoolim Sung, Soo Been Lee, Seong Who Kim, Eun-Ju Chang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell Communication and Signaling
Subjects:
SLIT3
Macrophages
Toll-like receptor 4 (TLR4)
miR-218–2-3p
RANK
Osteoclast commitment
Online Access:https://doi.org/10.1186/s12964-023-01226-w

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