Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.
Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic...
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MDPI AG
2016-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/6/739 |
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| author | Izabela Grzegorczyk-Karolak Krzysztof Gołąb Jakub Gburek Halina Wysokińska Adam Matkowski |
| author_facet | Izabela Grzegorczyk-Karolak Krzysztof Gołąb Jakub Gburek Halina Wysokińska Adam Matkowski |
| author_sort | Izabela Grzegorczyk-Karolak |
| collection | DOAJ |
| description | Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic compounds, had strong antiglycation properties. These extracts demonstrated also high activity in the FRAP (ferric-reducing antioxidant power), antiradical (DPPH) and lipid peroxidation inhibition assays. Among the pure compounds, baicalin was the strongest glycation inhibitor (90.4% inhibition at 100 μg/mL), followed by luteolin (85.4%). Two other flavone glycosides had about half of this activity. Verbascoside was similar to the reference drug aminoguanidine (71.2% and 75.9%, respectively). The strong correlation observed between AGE inhibition and total flavonoid content indicated that flavonoids contribute significantly to antiglycation properties. A positive correlation was also observed between antiglycative and antioxidant activities. The studied skullcap species can be considered as a potential source of therapeutic agents for hyperglycemia-related disorders. |
| first_indexed | 2024-12-11T09:24:10Z |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T09:24:10Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c1aa8ef6c3e54ae6a6df812fc5ff9fba2022-12-22T01:13:12ZengMDPI AGMolecules1420-30492016-06-0121673910.3390/molecules21060739molecules21060739Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.Izabela Grzegorczyk-Karolak0Krzysztof Gołąb1Jakub Gburek2Halina Wysokińska3Adam Matkowski4Department of Biology and Pharmaceutical Botany, Medical University of Lodz, ul. Muszynskiego 1, Lodz 90–151, PolandDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, ul. Borowska 211A, Wroclaw 50-556, PolandDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, ul. Borowska 211A, Wroclaw 50-556, PolandDepartment of Biology and Pharmaceutical Botany, Medical University of Lodz, ul. Muszynskiego 1, Lodz 90–151, PolandDepartment of Biology and Pharmaceutical Botany, Wroclaw Medical University, ul. Borowska 211, Wroclaw 50-556, PolandMethanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic compounds, had strong antiglycation properties. These extracts demonstrated also high activity in the FRAP (ferric-reducing antioxidant power), antiradical (DPPH) and lipid peroxidation inhibition assays. Among the pure compounds, baicalin was the strongest glycation inhibitor (90.4% inhibition at 100 μg/mL), followed by luteolin (85.4%). Two other flavone glycosides had about half of this activity. Verbascoside was similar to the reference drug aminoguanidine (71.2% and 75.9%, respectively). The strong correlation observed between AGE inhibition and total flavonoid content indicated that flavonoids contribute significantly to antiglycation properties. A positive correlation was also observed between antiglycative and antioxidant activities. The studied skullcap species can be considered as a potential source of therapeutic agents for hyperglycemia-related disorders.http://www.mdpi.com/1420-3049/21/6/739advanced glycation end productsflavonoidsantioxidantsScutellaria alpinaScutellaria altissima |
| spellingShingle | Izabela Grzegorczyk-Karolak Krzysztof Gołąb Jakub Gburek Halina Wysokińska Adam Matkowski Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. Molecules advanced glycation end products flavonoids antioxidants Scutellaria alpina Scutellaria altissima |
| title | Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. |
| title_full | Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. |
| title_fullStr | Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. |
| title_full_unstemmed | Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. |
| title_short | Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. |
| title_sort | inhibition of advanced glycation end product formation and antioxidant activity by extracts and polyphenols from scutellaria alpina l and s altissima l |
| topic | advanced glycation end products flavonoids antioxidants Scutellaria alpina Scutellaria altissima |
| url | http://www.mdpi.com/1420-3049/21/6/739 |
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