Prognostic value of health-related quality of life in elderly patients hospitalized with heart failure
Predrag Erceg,1,2 Nebojsa Despotovic,1,2 Dragoslav P Milosevic,1,2 Ivan Soldatovic,1 Gordana Mihajlovic,1,2 Vladan Vukcevic,1,3 Predrag Mitrovic,1,3 Natasa Markovic-Nikolic,1,4 Milica Micovic,2 Dragica Mitrovic,5 Mladen Davidovic11Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Clini...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-05-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/prognostic-value-of-health-related-quality-of-life-in-elderly-patients-peer-reviewed-article-CIA |
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| author | Erceg P Despotovic N Milosevic DP Soldatovic I Mihajlovic G Vukcevic V Mitrovic P Markovic-Nikolic N Micovic M Mitrovic D Davidovic M |
| author_facet | Erceg P Despotovic N Milosevic DP Soldatovic I Mihajlovic G Vukcevic V Mitrovic P Markovic-Nikolic N Micovic M Mitrovic D Davidovic M |
| author_sort | Erceg P |
| collection | DOAJ |
| description | Predrag Erceg,1,2 Nebojsa Despotovic,1,2 Dragoslav P Milosevic,1,2 Ivan Soldatovic,1 Gordana Mihajlovic,1,2 Vladan Vukcevic,1,3 Predrag Mitrovic,1,3 Natasa Markovic-Nikolic,1,4 Milica Micovic,2 Dragica Mitrovic,5 Mladen Davidovic11Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinical Department of Geriatrics, “Zvezdara” University Hospital, Belgrade, Serbia; 3Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia; 4Clinical Department of Cardiology, “Zvezdara” University Hospital, Belgrade, Serbia; 5Department of Physical Medicine and Rehabilitation, “Zvezdara” University Hospital, Belgrade, SerbiaPurpose: Previous research has shown that poor health-related quality of life (HRQOL) is associated with adverse long-term prognosis in patients with heart failure (HF); however, there have been inconsistencies among studies and not all of them confirmed the prognostic value of HRQOL. In addition, few studies involved elderly patients and most focused on all-cause mortality and HF-related hospitalization as outcomes. The aim of our study was to determine whether HRQOL is a predictor and an independent predictor of long-term cardiac mortality, all-cause mortality, and HF-related rehospitalization in elderly patients hospitalized with HF.Patients and methods: This prospective observational study included 200 elderly patients hospitalized with HF in Serbia. HRQOL was measured using the Minnesota Living with Heart Failure questionnaire (MLHFQ). The median follow-up period was 28 months. The primary outcome was cardiac mortality, and all-cause mortality and HF-related rehospitalization were secondary outcomes. Survival analysis was conducted using the Kaplan–Meier method and Cox-proportional hazards regression.Results: Subjects with poor HRQOL (higher than the median MLHFQ score) had a higher probability of cardiac mortality (P=0.029) and HF-related rehospitalization (P=0.001) during long-term follow-up. Poor HRQOL was an independent predictor of cardiac mortality (HR: 2.051, 95% CI: 1.260–3.339, P=0.004), all-cause mortality (HR: 1.620, 95% CI: 1.076–2.438, P=0.021), and HF-related rehospitalization (HR: 2.040, 95% CI: 1.290–3.227, P=0.002).Conclusion: HRQOL is an independent predictor of long-term cardiac mortality in elderly patients hospitalized with HF. It also independently predicts all-cause mortality and HF-related rehospitalization. HRQOL could be used as a complementary clinical predictive tool in this patient population.Keywords: aged, heart disease, self-perception of health, prognosis |
| first_indexed | 2024-12-19T08:11:08Z |
| format | Article |
| id | doaj.art-c1ab5d5cae74436fa4dcf0def8857920 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-19T08:11:08Z |
| publishDate | 2019-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-c1ab5d5cae74436fa4dcf0def88579202022-12-21T20:29:37ZengDove Medical PressClinical Interventions in Aging1178-19982019-05-01Volume 1493594545961Prognostic value of health-related quality of life in elderly patients hospitalized with heart failureErceg PDespotovic NMilosevic DPSoldatovic IMihajlovic GVukcevic VMitrovic PMarkovic-Nikolic NMicovic MMitrovic DDavidovic MPredrag Erceg,1,2 Nebojsa Despotovic,1,2 Dragoslav P Milosevic,1,2 Ivan Soldatovic,1 Gordana Mihajlovic,1,2 Vladan Vukcevic,1,3 Predrag Mitrovic,1,3 Natasa Markovic-Nikolic,1,4 Milica Micovic,2 Dragica Mitrovic,5 Mladen Davidovic11Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinical Department of Geriatrics, “Zvezdara” University Hospital, Belgrade, Serbia; 3Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia; 4Clinical Department of Cardiology, “Zvezdara” University Hospital, Belgrade, Serbia; 5Department of Physical Medicine and Rehabilitation, “Zvezdara” University Hospital, Belgrade, SerbiaPurpose: Previous research has shown that poor health-related quality of life (HRQOL) is associated with adverse long-term prognosis in patients with heart failure (HF); however, there have been inconsistencies among studies and not all of them confirmed the prognostic value of HRQOL. In addition, few studies involved elderly patients and most focused on all-cause mortality and HF-related hospitalization as outcomes. The aim of our study was to determine whether HRQOL is a predictor and an independent predictor of long-term cardiac mortality, all-cause mortality, and HF-related rehospitalization in elderly patients hospitalized with HF.Patients and methods: This prospective observational study included 200 elderly patients hospitalized with HF in Serbia. HRQOL was measured using the Minnesota Living with Heart Failure questionnaire (MLHFQ). The median follow-up period was 28 months. The primary outcome was cardiac mortality, and all-cause mortality and HF-related rehospitalization were secondary outcomes. Survival analysis was conducted using the Kaplan–Meier method and Cox-proportional hazards regression.Results: Subjects with poor HRQOL (higher than the median MLHFQ score) had a higher probability of cardiac mortality (P=0.029) and HF-related rehospitalization (P=0.001) during long-term follow-up. Poor HRQOL was an independent predictor of cardiac mortality (HR: 2.051, 95% CI: 1.260–3.339, P=0.004), all-cause mortality (HR: 1.620, 95% CI: 1.076–2.438, P=0.021), and HF-related rehospitalization (HR: 2.040, 95% CI: 1.290–3.227, P=0.002).Conclusion: HRQOL is an independent predictor of long-term cardiac mortality in elderly patients hospitalized with HF. It also independently predicts all-cause mortality and HF-related rehospitalization. HRQOL could be used as a complementary clinical predictive tool in this patient population.Keywords: aged, heart disease, self-perception of health, prognosishttps://www.dovepress.com/prognostic-value-of-health-related-quality-of-life-in-elderly-patients-peer-reviewed-article-CIAagedheart diseaseself-perception of healthprognosis |
| spellingShingle | Erceg P Despotovic N Milosevic DP Soldatovic I Mihajlovic G Vukcevic V Mitrovic P Markovic-Nikolic N Micovic M Mitrovic D Davidovic M Prognostic value of health-related quality of life in elderly patients hospitalized with heart failure Clinical Interventions in Aging aged heart disease self-perception of health prognosis |
| title | Prognostic value of health-related quality of life in elderly patients hospitalized with heart failure |
| title_full | Prognostic value of health-related quality of life in elderly patients hospitalized with heart failure |
| title_fullStr | Prognostic value of health-related quality of life in elderly patients hospitalized with heart failure |
| title_full_unstemmed | Prognostic value of health-related quality of life in elderly patients hospitalized with heart failure |
| title_short | Prognostic value of health-related quality of life in elderly patients hospitalized with heart failure |
| title_sort | prognostic value of health related quality of life in elderly patients hospitalized with heart failure |
| topic | aged heart disease self-perception of health prognosis |
| url | https://www.dovepress.com/prognostic-value-of-health-related-quality-of-life-in-elderly-patients-peer-reviewed-article-CIA |
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