Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers
Dysregulated surface glycoproteins play an important role in tumor cell proliferation and progression. Abnormal glycosylation of these glycoproteins may activate tumor signal transduction and lead to tumor development. The tumor microenvironment alters its molecular composition, some of which regula...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Pharmacology and Drug Discovery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590257121000663 |
| _version_ | 1811293842987548672 |
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| author | Ziyuan Gao Mingming Xu Shuang Yue Huang Shan Jun Xia Junhong Jiang Shuang Yang |
| author_facet | Ziyuan Gao Mingming Xu Shuang Yue Huang Shan Jun Xia Junhong Jiang Shuang Yang |
| author_sort | Ziyuan Gao |
| collection | DOAJ |
| description | Dysregulated surface glycoproteins play an important role in tumor cell proliferation and progression. Abnormal glycosylation of these glycoproteins may activate tumor signal transduction and lead to tumor development. The tumor microenvironment alters its molecular composition, some of which regulate protein glycosylation biosynthesis. The glycosylation of saliva proteins in lung cancer patients is different from healthy controls, in which the glycans of cancer patients are highly sialylated and hyperfucosylated. Most studies have shown that O-glycans from cancer are truncated O-glycans, while N-glycans contain fucoses and sialic acids. Because glycosylation analysis is challenging, there are few reports on how glycosylation of saliva proteins is related to the occurrence or progression of lung cancer. In this review, we discussed glycoenzymes involved in protein glycosylation, their changes in tumor microenvironment, potential tumor biomarkers present in body fluids, and abnormal glycosylation of saliva or lung glycoproteins. We further explored the effect of glycosylation changes on tumor signal transduction, and emphasized the role of receptor tyrosine kinases in tumorigenesis and metastasis. |
| first_indexed | 2024-04-13T05:08:36Z |
| format | Article |
| id | doaj.art-c1ab793e454445339e554bf58ff163a2 |
| institution | Directory Open Access Journal |
| issn | 2590-2571 |
| language | English |
| last_indexed | 2024-04-13T05:08:36Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Pharmacology and Drug Discovery |
| spelling | doaj.art-c1ab793e454445339e554bf58ff163a22022-12-22T03:01:07ZengElsevierCurrent Research in Pharmacology and Drug Discovery2590-25712022-01-013100079Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkersZiyuan Gao0Mingming Xu1Shuang Yue2Huang Shan3Jun Xia4Junhong Jiang5Shuang Yang6Center for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Jiangsu, 215123, China; Department of Respiratory and Critical Care Medicine, Dushu Lake Hospital to Soochow University, Suzhou, Jiangsu, 215125, China; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Soochow University; Suzhou Jiangsu, 215006, ChinaCenter for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Jiangsu, 215123, ChinaCenter for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Jiangsu, 215123, ChinaCenter for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Jiangsu, 215123, ChinaDepartment of Clinical Laboratory Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, 310014, ChinaDepartment of Respiratory and Critical Care Medicine, Dushu Lake Hospital to Soochow University, Suzhou, Jiangsu, 215125, China; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Soochow University; Suzhou Jiangsu, 215006, China; Corresponding author. 9 Chong Wen Rd, Dushu Lake Hospital to Soochow University, Suzhou, Jiangsu, 215125, China.Center for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Jiangsu, 215123, China; Corresponding author. 2107 Yunxuan Bldg, 199 Ren’Ai Road, Dushu Lake Campus, Soochow University, Jiangsu, 215123, China.Dysregulated surface glycoproteins play an important role in tumor cell proliferation and progression. Abnormal glycosylation of these glycoproteins may activate tumor signal transduction and lead to tumor development. The tumor microenvironment alters its molecular composition, some of which regulate protein glycosylation biosynthesis. The glycosylation of saliva proteins in lung cancer patients is different from healthy controls, in which the glycans of cancer patients are highly sialylated and hyperfucosylated. Most studies have shown that O-glycans from cancer are truncated O-glycans, while N-glycans contain fucoses and sialic acids. Because glycosylation analysis is challenging, there are few reports on how glycosylation of saliva proteins is related to the occurrence or progression of lung cancer. In this review, we discussed glycoenzymes involved in protein glycosylation, their changes in tumor microenvironment, potential tumor biomarkers present in body fluids, and abnormal glycosylation of saliva or lung glycoproteins. We further explored the effect of glycosylation changes on tumor signal transduction, and emphasized the role of receptor tyrosine kinases in tumorigenesis and metastasis.http://www.sciencedirect.com/science/article/pii/S2590257121000663GlycoenzymeGlycosylationSalivaTumor biomarkerMass spectrometry |
| spellingShingle | Ziyuan Gao Mingming Xu Shuang Yue Huang Shan Jun Xia Junhong Jiang Shuang Yang Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers Current Research in Pharmacology and Drug Discovery Glycoenzyme Glycosylation Saliva Tumor biomarker Mass spectrometry |
| title | Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers |
| title_full | Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers |
| title_fullStr | Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers |
| title_full_unstemmed | Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers |
| title_short | Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers |
| title_sort | abnormal sialylation and fucosylation of saliva glycoproteins characteristics of lung cancer specific biomarkers |
| topic | Glycoenzyme Glycosylation Saliva Tumor biomarker Mass spectrometry |
| url | http://www.sciencedirect.com/science/article/pii/S2590257121000663 |
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