Design, synthesis and biological activity of pyrazinamide derivatives for anti-Mycobacterium tuberculosis

Design, synthesis and biological activity of pyrazinamide derivatives for anti-Mycobacterium tuberculosis

A total of 11 pyrazinamide derivatives were designed and synthesised using pyrazinamide as the lead compound, which was optimised by structural modification with alkyl chains, six-membered rings, and bioisosterism, respectively. The target compounds were synthesised using pyrazinecarboxylic acid as...

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Bibliographic Details
Main Authors: Shiyang Zhou, Shanbin Yang, Gangliang Huang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Pyrazinamide
derivatives
design
synthesis
biological activity
Online Access:http://dx.doi.org/10.1080/14756366.2017.1367774

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