Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized study
IntroductionStroke is the leading cause of functional disability worldwide. With the increase of the global population, motor rehabilitation of stroke survivors is of ever-increasing importance. In the last decade, virtual reality (VR) technologies for rehabilitation have been extensively studied, t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1241639/full |
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| author | Jamille Almeida Feitosa Jamille Almeida Feitosa Raphael Fernandes Casseb Raphael Fernandes Casseb Alline Camargo Alexandre Fonseca Brandao Alexandre Fonseca Brandao Li Min Li Li Min Li Gabriela Castellano Gabriela Castellano |
| author_facet | Jamille Almeida Feitosa Jamille Almeida Feitosa Raphael Fernandes Casseb Raphael Fernandes Casseb Alline Camargo Alexandre Fonseca Brandao Alexandre Fonseca Brandao Li Min Li Li Min Li Gabriela Castellano Gabriela Castellano |
| author_sort | Jamille Almeida Feitosa |
| collection | DOAJ |
| description | IntroductionStroke is the leading cause of functional disability worldwide. With the increase of the global population, motor rehabilitation of stroke survivors is of ever-increasing importance. In the last decade, virtual reality (VR) technologies for rehabilitation have been extensively studied, to be used instead of or together with conventional treatments such as physiotherapy or occupational therapy. The aim of this work was to evaluate the GestureCollection VR-based rehabilitation tool in terms of the brain changes and clinical outcomes of the patients.MethodsTwo groups of chronic patients underwent a rehabilitation treatment with (experimental) or without (control) complementation with GestureCollection. Functional magnetic resonance imaging exams and clinical assessments were performed before and after the treatment. A functional connectivity graph-based analysis was used to assess differences between the connections and in the network parameters strength and clustering coefficient.ResultsPatients in both groups showed improvement in clinical scales, but there were more increases in functional connectivity in the experimental group than in the control group.DiscussionThe experimental group presented changes in the connections between the frontoparietal and the somatomotor networks, associative cerebellum and basal ganglia, which are regions associated with reward-based motor learning. On the other hand, the control group also had results in the somatomotor network, in its ipsilateral connections with the thalamus and with the motor cerebellum, which are regions more related to a purely mechanical activity. Thus, the use of the GestureCollection system was successfully shown to promote neuroplasticity in several motor-related areas. |
| first_indexed | 2024-03-11T19:42:50Z |
| format | Article |
| id | doaj.art-c1aeeef2517e46be93989aa7a290edee |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T19:42:50Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c1aeeef2517e46be93989aa7a290edee2023-10-06T07:43:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.12416391241639Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized studyJamille Almeida Feitosa0Jamille Almeida Feitosa1Raphael Fernandes Casseb2Raphael Fernandes Casseb3Alline Camargo4Alexandre Fonseca Brandao5Alexandre Fonseca Brandao6Li Min Li7Li Min Li8Gabriela Castellano9Gabriela Castellano10Gleb Wataghin Institute of Physics, University of Campinas – UNICAMP, Campinas, BrazilBrazilian Institute of Neuroscience and Neurotechnology – BRAINN, Campinas, BrazilBrazilian Institute of Neuroscience and Neurotechnology – BRAINN, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas – UNICAMP, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas – UNICAMP, Campinas, BrazilGleb Wataghin Institute of Physics, University of Campinas – UNICAMP, Campinas, BrazilBrazilian Institute of Neuroscience and Neurotechnology – BRAINN, Campinas, BrazilBrazilian Institute of Neuroscience and Neurotechnology – BRAINN, Campinas, BrazilNeuroimaging Laboratory, Department of Neurology, University of Campinas – UNICAMP, Campinas, BrazilGleb Wataghin Institute of Physics, University of Campinas – UNICAMP, Campinas, BrazilBrazilian Institute of Neuroscience and Neurotechnology – BRAINN, Campinas, BrazilIntroductionStroke is the leading cause of functional disability worldwide. With the increase of the global population, motor rehabilitation of stroke survivors is of ever-increasing importance. In the last decade, virtual reality (VR) technologies for rehabilitation have been extensively studied, to be used instead of or together with conventional treatments such as physiotherapy or occupational therapy. The aim of this work was to evaluate the GestureCollection VR-based rehabilitation tool in terms of the brain changes and clinical outcomes of the patients.MethodsTwo groups of chronic patients underwent a rehabilitation treatment with (experimental) or without (control) complementation with GestureCollection. Functional magnetic resonance imaging exams and clinical assessments were performed before and after the treatment. A functional connectivity graph-based analysis was used to assess differences between the connections and in the network parameters strength and clustering coefficient.ResultsPatients in both groups showed improvement in clinical scales, but there were more increases in functional connectivity in the experimental group than in the control group.DiscussionThe experimental group presented changes in the connections between the frontoparietal and the somatomotor networks, associative cerebellum and basal ganglia, which are regions associated with reward-based motor learning. On the other hand, the control group also had results in the somatomotor network, in its ipsilateral connections with the thalamus and with the motor cerebellum, which are regions more related to a purely mechanical activity. Thus, the use of the GestureCollection system was successfully shown to promote neuroplasticity in several motor-related areas.https://www.frontiersin.org/articles/10.3389/fneur.2023.1241639/fullstrokefunctional connectivitygraph theoryvirtual realityneuroplasticity |
| spellingShingle | Jamille Almeida Feitosa Jamille Almeida Feitosa Raphael Fernandes Casseb Raphael Fernandes Casseb Alline Camargo Alexandre Fonseca Brandao Alexandre Fonseca Brandao Li Min Li Li Min Li Gabriela Castellano Gabriela Castellano Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized study Frontiers in Neurology stroke functional connectivity graph theory virtual reality neuroplasticity |
| title | Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized study |
| title_full | Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized study |
| title_fullStr | Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized study |
| title_full_unstemmed | Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized study |
| title_short | Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized study |
| title_sort | graph analysis of cortical reorganization after virtual reality based rehabilitation following stroke a pilot randomized study |
| topic | stroke functional connectivity graph theory virtual reality neuroplasticity |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1241639/full |
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