A National Hospital‐Based Study of Hospitalized Patients With Primary Biliary Cholangitis
Epidemiological studies on primary biliary cholangitis (PBC) have been based primarily on tertiary referral case series. We aimed to estimate the incidence and prevalence and describe comorbidities in hospitalized patients with PBC in Italy using a national hospital‐based data source. Data were extr...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
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Wolters Kluwer Health/LWW
2019-09-01
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Series: | Hepatology Communications |
Online Access: | https://doi.org/10.1002/hep4.1407 |
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author | Valerio Manno Alessio Gerussi Marco Carbone Giada Minelli Domenica Taruscio Susanna Conti Pietro Invernizzi |
author_facet | Valerio Manno Alessio Gerussi Marco Carbone Giada Minelli Domenica Taruscio Susanna Conti Pietro Invernizzi |
author_sort | Valerio Manno |
collection | DOAJ |
description | Epidemiological studies on primary biliary cholangitis (PBC) have been based primarily on tertiary referral case series. We aimed to estimate the incidence and prevalence and describe comorbidities in hospitalized patients with PBC in Italy using a national hospital‐based data source. Data were extracted from the National Hospital Discharge Database, which includes all Italian individuals discharged from any hospital in the country. All adults diagnosed with biliary cirrhosis (International Classification of Diseases, Ninth Revision, Clinical Modification, 571.6) as the primary or secondary diagnosis from 2011 to 2015 were included. To determine whether a comorbidity was either more or less frequent in PBC patients compared with the general hospitalized Italian population, the standardized hospitalization ratio (SHR) was calculated. A total of 5,533 incident cases were identified from 2011 to 2015, 3,790 of whom were females (68.5%; female to male [F:M] ratio, 2.2:1). Prevalent cases were 9,664, of whom 7,209 were females (74.6%; F:M ratio, 2.9:1). The incident rate was 1.03 × 100,000 in males and 1.92 × 100,000 in females; prevalence was 1.89 × 100,000 in males and 4.75 × 100,000 in females. Extrahepatic autoimmune diseases, malignant neoplasms of liver and intrahepatic biliary ducts, and malignant neoplasms of gallbladder and extrahepatic bile ducts were found more frequently in PBC patients than in the general hospitalized population (SHR > 100), whereas cerebrovascular diseases and ischemic heart diseases were less frequent in PBC individuals (SHR < 100). Conclusion: This national study provides a survey of comorbidities associated with PBC. Hospitalized patients with PBC are more likely to have extrahepatic autoimmune diseases, hepatocellular carcinoma, and biliary tract cancers and a low risk of cardiovascular events. |
first_indexed | 2024-03-12T18:10:38Z |
format | Article |
id | doaj.art-c1af914f8d904d86989bafdd4b8bc268 |
institution | Directory Open Access Journal |
issn | 2471-254X |
language | English |
last_indexed | 2024-03-12T18:10:38Z |
publishDate | 2019-09-01 |
publisher | Wolters Kluwer Health/LWW |
record_format | Article |
series | Hepatology Communications |
spelling | doaj.art-c1af914f8d904d86989bafdd4b8bc2682023-08-02T09:15:50ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2019-09-01391250125710.1002/hep4.1407A National Hospital‐Based Study of Hospitalized Patients With Primary Biliary CholangitisValerio Manno0Alessio Gerussi1Marco Carbone2Giada Minelli3Domenica Taruscio4Susanna Conti5Pietro Invernizzi6Service of Statistics National Institute of Health Rome ItalyDivision of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery University of Milano‐Bicocca Monza ItalyDivision of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery University of Milano‐Bicocca Monza ItalyService of Statistics National Institute of Health Rome ItalyNational Center for Rare Diseases National Institute of Health Rome ItalyService of Statistics National Institute of Health Rome ItalyDivision of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery University of Milano‐Bicocca Monza ItalyEpidemiological studies on primary biliary cholangitis (PBC) have been based primarily on tertiary referral case series. We aimed to estimate the incidence and prevalence and describe comorbidities in hospitalized patients with PBC in Italy using a national hospital‐based data source. Data were extracted from the National Hospital Discharge Database, which includes all Italian individuals discharged from any hospital in the country. All adults diagnosed with biliary cirrhosis (International Classification of Diseases, Ninth Revision, Clinical Modification, 571.6) as the primary or secondary diagnosis from 2011 to 2015 were included. To determine whether a comorbidity was either more or less frequent in PBC patients compared with the general hospitalized Italian population, the standardized hospitalization ratio (SHR) was calculated. A total of 5,533 incident cases were identified from 2011 to 2015, 3,790 of whom were females (68.5%; female to male [F:M] ratio, 2.2:1). Prevalent cases were 9,664, of whom 7,209 were females (74.6%; F:M ratio, 2.9:1). The incident rate was 1.03 × 100,000 in males and 1.92 × 100,000 in females; prevalence was 1.89 × 100,000 in males and 4.75 × 100,000 in females. Extrahepatic autoimmune diseases, malignant neoplasms of liver and intrahepatic biliary ducts, and malignant neoplasms of gallbladder and extrahepatic bile ducts were found more frequently in PBC patients than in the general hospitalized population (SHR > 100), whereas cerebrovascular diseases and ischemic heart diseases were less frequent in PBC individuals (SHR < 100). Conclusion: This national study provides a survey of comorbidities associated with PBC. Hospitalized patients with PBC are more likely to have extrahepatic autoimmune diseases, hepatocellular carcinoma, and biliary tract cancers and a low risk of cardiovascular events.https://doi.org/10.1002/hep4.1407 |
spellingShingle | Valerio Manno Alessio Gerussi Marco Carbone Giada Minelli Domenica Taruscio Susanna Conti Pietro Invernizzi A National Hospital‐Based Study of Hospitalized Patients With Primary Biliary Cholangitis Hepatology Communications |
title | A National Hospital‐Based Study of Hospitalized Patients With Primary Biliary Cholangitis |
title_full | A National Hospital‐Based Study of Hospitalized Patients With Primary Biliary Cholangitis |
title_fullStr | A National Hospital‐Based Study of Hospitalized Patients With Primary Biliary Cholangitis |
title_full_unstemmed | A National Hospital‐Based Study of Hospitalized Patients With Primary Biliary Cholangitis |
title_short | A National Hospital‐Based Study of Hospitalized Patients With Primary Biliary Cholangitis |
title_sort | national hospital based study of hospitalized patients with primary biliary cholangitis |
url | https://doi.org/10.1002/hep4.1407 |
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