Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease
Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and mortality, and the search for novel diagnostic and therapeutic methods is ongoing. Mitochondrial DNA (mtDNA) mutations associated with atherosclerosis represent one of the less explored aspects of the disease p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/9/8/377 |
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| author | Aleksandrina Volobueva Andrey Grechko Shaw-Fang Yet Igor Sobenin Alexander Orekhov |
| author_facet | Aleksandrina Volobueva Andrey Grechko Shaw-Fang Yet Igor Sobenin Alexander Orekhov |
| author_sort | Aleksandrina Volobueva |
| collection | DOAJ |
| description | Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and mortality, and the search for novel diagnostic and therapeutic methods is ongoing. Mitochondrial DNA (mtDNA) mutations associated with atherosclerosis represent one of the less explored aspects of the disease pathogenesis that may bring some interesting opportunities for establishing novel molecular markers and, possibly, new points of therapeutic intervention. Recent studies have identified a number of mtDNA mutations, for which the heteroplasmy level was positively or negatively associated with atherosclerosis, including the disease at its early, subclinical stages. In this review, we summarize the results of these studies, providing a list of human mtDNA mutations potentially involved in atherosclerosis. The molecular mechanisms underlying such involvement remain to be elucidated, although it is likely that some of them may be responsible for the increased oxidative stress, which plays an important role in atherosclerosis. |
| first_indexed | 2024-12-23T19:38:07Z |
| format | Article |
| id | doaj.art-c1b037dd4ebd41bdaa04c4ba39022ab3 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-23T19:38:07Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-c1b037dd4ebd41bdaa04c4ba39022ab32022-12-21T17:33:44ZengMDPI AGBiomolecules2218-273X2019-08-019837710.3390/biom9080377biom9080377Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related DiseaseAleksandrina Volobueva0Andrey Grechko1Shaw-Fang Yet2Igor Sobenin3Alexander Orekhov4Laboratory of Gene Therapy, Biocad Biotechnology Company, Saint-Petersburg, Strelnya 198515, RussiaFederal Scientific Clinical Center for Resuscitation and Rehabilitation, Moscow 109240, RussiaInstitute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 35053, TaiwanLaboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, RussiaInstitute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 121609, RussiaAtherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and mortality, and the search for novel diagnostic and therapeutic methods is ongoing. Mitochondrial DNA (mtDNA) mutations associated with atherosclerosis represent one of the less explored aspects of the disease pathogenesis that may bring some interesting opportunities for establishing novel molecular markers and, possibly, new points of therapeutic intervention. Recent studies have identified a number of mtDNA mutations, for which the heteroplasmy level was positively or negatively associated with atherosclerosis, including the disease at its early, subclinical stages. In this review, we summarize the results of these studies, providing a list of human mtDNA mutations potentially involved in atherosclerosis. The molecular mechanisms underlying such involvement remain to be elucidated, although it is likely that some of them may be responsible for the increased oxidative stress, which plays an important role in atherosclerosis.https://www.mdpi.com/2218-273X/9/8/377atherosclerosismitochondriamtDNAmutationsheteroplasmymolecular markers |
| spellingShingle | Aleksandrina Volobueva Andrey Grechko Shaw-Fang Yet Igor Sobenin Alexander Orekhov Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease Biomolecules atherosclerosis mitochondria mtDNA mutations heteroplasmy molecular markers |
| title | Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease |
| title_full | Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease |
| title_fullStr | Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease |
| title_full_unstemmed | Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease |
| title_short | Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease |
| title_sort | changes in mitochondrial genome associated with predisposition to atherosclerosis and related disease |
| topic | atherosclerosis mitochondria mtDNA mutations heteroplasmy molecular markers |
| url | https://www.mdpi.com/2218-273X/9/8/377 |
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