Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsia
Objective: To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE). Methods: The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32. Result...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-07-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2021.1958836 |
| _version_ | 1797681543914717184 |
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| author | Fatemeh Mazlum Behrouz Gharesi-Fard Hossein Hadinedoushan Yousef Bakhshizadeh Ghashti |
| author_facet | Fatemeh Mazlum Behrouz Gharesi-Fard Hossein Hadinedoushan Yousef Bakhshizadeh Ghashti |
| author_sort | Fatemeh Mazlum |
| collection | DOAJ |
| description | Objective: To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE). Methods: The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32. Results: Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients. Conclusion: Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE. |
| first_indexed | 2024-03-11T23:46:22Z |
| format | Article |
| id | doaj.art-c1b1793e1758474cb2d02e73952741ab |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:46:22Z |
| publishDate | 2021-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-c1b1793e1758474cb2d02e73952741ab2023-09-19T09:24:44ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652021-07-0140321822510.1080/10641955.2021.19588361958836Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsiaFatemeh Mazlum0Behrouz Gharesi-Fard1Hossein Hadinedoushan2Yousef Bakhshizadeh Ghashti3Shahid Sadoughi University of Medical SciencesShiraz University of Medical SciencesShahid Sadoughi University of Medical SciencesChabahar Maritime UniversityObjective: To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE). Methods: The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32. Results: Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients. Conclusion: Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE.http://dx.doi.org/10.1080/10641955.2021.1958836gene polymorphismil-32preeclampsiapregnancy |
| spellingShingle | Fatemeh Mazlum Behrouz Gharesi-Fard Hossein Hadinedoushan Yousef Bakhshizadeh Ghashti Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsia Hypertension in Pregnancy gene polymorphism il-32 preeclampsia pregnancy |
| title | Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsia |
| title_full | Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsia |
| title_fullStr | Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsia |
| title_full_unstemmed | Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsia |
| title_short | Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia: Running Head: Association of IL-32 and preeclampsia |
| title_sort | association between interleukin 32 gene polymorphism and susceptibility to preeclampsia running head association of il 32 and preeclampsia |
| topic | gene polymorphism il-32 preeclampsia pregnancy |
| url | http://dx.doi.org/10.1080/10641955.2021.1958836 |
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