Identification of a Novel Class of Anti-Melanogenic Compounds, (<i>Z</i>)-5-(Substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one Derivatives, and Their Reactive Oxygen Species Scavenging Activities

Identification of a Novel Class of Anti-Melanogenic Compounds, (<i>Z</i>)-5-(Substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one Derivatives, and Their Reactive Oxygen Species Scavenging Activities

The rate-determining role of tyrosinase makes it a critical component in the mechanism that is responsible for melanogenesis. Thirteen (<i>Z</i>)-5-(substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one ((<i>Z</i>)-BPTT) analogs were designed based on the structural fea...

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Bibliographic Details
Main Authors: Yeongmu Jeong, Sojeong Hong, Hee Jin Jung, Sultan Ullah, YeJi Hwang, Heejeong Choi, Jeongin Ko, Jieun Lee, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Antioxidants
Subjects:
tyrosinase
ROS
radical scavenging
docking simulation
anti-melanogenesis
dual mechanism
Online Access:https://www.mdpi.com/2076-3921/11/5/948

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