Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in Human
To meet the demand for alternatives to commonly used antibiotics, this paper evaluates the antimicrobial potential of arene-ruthenium(II) complexes and their salts, which may be of value in antibacterial treatment. Their antimicrobial activity (MIC, MBC/MFC) was examined in vitro against <i>St...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/2/468 |
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| author | Ewelina Namiecińska Magdalena Grazul Beata Sadowska Marzena Więckowska-Szakiel Paweł Hikisz Beata Pasternak Elzbieta Budzisz |
| author_facet | Ewelina Namiecińska Magdalena Grazul Beata Sadowska Marzena Więckowska-Szakiel Paweł Hikisz Beata Pasternak Elzbieta Budzisz |
| author_sort | Ewelina Namiecińska |
| collection | DOAJ |
| description | To meet the demand for alternatives to commonly used antibiotics, this paper evaluates the antimicrobial potential of arene-ruthenium(II) complexes and their salts, which may be of value in antibacterial treatment. Their antimicrobial activity (MIC, MBC/MFC) was examined in vitro against <i>Staphylococcus aureus</i>, <i>Staphylococcus epidermidis</i>, <i>Enterococcus faecalis</i>, <i>Pseudomonas aeruginosa, Proteus vulgaris</i> and <i>Candida albicans</i> and compared with classic antibiotics used as therapeutics. Selected arene-ruthenium(II) complexes were found to have synergistic effects with oxacillin and vancomycin against staphylococci. Their bactericidal effect was found to be associated with cell lysis and the ability to cut microbial DNA. To confirm the safety of the tested arene-ruthenium(II) complexes in vivo, their cytotoxicity was also investigated against normal human foreskin fibroblasts (HFF-1). In addition, the antioxidant and thus pro-health potential of the compounds, i.e., their nonenzymatic antioxidant capacity (NEAC), was determined by two different methods: ferric-TPTZ complex and DPPH assay. |
| first_indexed | 2024-03-10T00:50:18Z |
| format | Article |
| id | doaj.art-c1b226453f5e4363aab54e78e185fa4e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T00:50:18Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c1b226453f5e4363aab54e78e185fa4e2023-11-23T14:52:24ZengMDPI AGMolecules1420-30492022-01-0127246810.3390/molecules27020468Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in HumanEwelina Namiecińska0Magdalena Grazul1Beata Sadowska2Marzena Więckowska-Szakiel3Paweł Hikisz4Beata Pasternak5Elzbieta Budzisz6Department of the Chemistry of Cosmetic Raw Materials, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, PolandDepartment of Pharmaceutical Microbiology and Microbiological Diagnostics, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, PolandDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandDepartment of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, PolandDepartment of the Chemistry of Cosmetic Raw Materials, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, PolandTo meet the demand for alternatives to commonly used antibiotics, this paper evaluates the antimicrobial potential of arene-ruthenium(II) complexes and their salts, which may be of value in antibacterial treatment. Their antimicrobial activity (MIC, MBC/MFC) was examined in vitro against <i>Staphylococcus aureus</i>, <i>Staphylococcus epidermidis</i>, <i>Enterococcus faecalis</i>, <i>Pseudomonas aeruginosa, Proteus vulgaris</i> and <i>Candida albicans</i> and compared with classic antibiotics used as therapeutics. Selected arene-ruthenium(II) complexes were found to have synergistic effects with oxacillin and vancomycin against staphylococci. Their bactericidal effect was found to be associated with cell lysis and the ability to cut microbial DNA. To confirm the safety of the tested arene-ruthenium(II) complexes in vivo, their cytotoxicity was also investigated against normal human foreskin fibroblasts (HFF-1). In addition, the antioxidant and thus pro-health potential of the compounds, i.e., their nonenzymatic antioxidant capacity (NEAC), was determined by two different methods: ferric-TPTZ complex and DPPH assay.https://www.mdpi.com/1420-3049/27/2/468antimicrobialantibacterialantioxidantarene-ruthenium(II) complexesantibiotic resistanceantibiotics |
| spellingShingle | Ewelina Namiecińska Magdalena Grazul Beata Sadowska Marzena Więckowska-Szakiel Paweł Hikisz Beata Pasternak Elzbieta Budzisz Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in Human Molecules antimicrobial antibacterial antioxidant arene-ruthenium(II) complexes antibiotic resistance antibiotics |
| title | Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in Human |
| title_full | Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in Human |
| title_fullStr | Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in Human |
| title_full_unstemmed | Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in Human |
| title_short | Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in Human |
| title_sort | arene ruthenium ii complexes with carbothiamidopyrazoles as a potential alternative for antibiotic resistance in human |
| topic | antimicrobial antibacterial antioxidant arene-ruthenium(II) complexes antibiotic resistance antibiotics |
| url | https://www.mdpi.com/1420-3049/27/2/468 |
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