Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years
Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry, Medical University of Gdansk, Gdansk...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/sports-participation-promotes-beneficial-adaptations-in-the-erythrocyt-peer-reviewed-fulltext-article-CIA |
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| author | Pospieszna B Kusy K Slominska EM Ciekot-Sołtysiak M Zieliński J |
| author_facet | Pospieszna B Kusy K Slominska EM Ciekot-Sołtysiak M Zieliński J |
| author_sort | Pospieszna B |
| collection | DOAJ |
| description | Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry, Medical University of Gdansk, Gdansk, PolandCorrespondence: Barbara Pospieszna, Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Królowej Jadwigi 27/39, Poznan, 61-871, Poland, Tel +48-618-355-270, Email bpospieszna@awf.poznan.plIntroduction: The guanine nucleotide pool (GTP, guanosine-5’-triphosphate; GDP, guanosine-5’-diphosphate, and GMP, guanosine-5’-monophosphate) is an essential energy donor in various biological processes (eg protein synthesis and gluconeogenesis) and secures several vital regulatory functions in the human body. The study aimed to predict the trends of age-related changes in erythrocyte guanine nucleotides and examine whether competitive sport and related physical training promote beneficial adaptations in erythrocyte guanylate concentrations.Methods: The study included 86 elite endurance runners (EN) aged 20– 81 years, 58 sprint-trained athletes (SP) aged 21– 90 years, and 62 untrained individuals (CO) aged 20– 68 years.Results: The concentration of erythrocyte GTP and total guanine nucleotides (TGN) were highest in the SP group, lower in the EN group, and lowest in the CO group. Both athletic groups had higher guanylate energy charge (GEC) values than the CO group (p = 0.012). Concentrations of GTP, TGN, and GEC value significantly decreased, while GDP and GMP concentrations progressively increased with age.Conclusion: Such a profile of change suggests a deterioration of the GTP-related regulatory function in older individuals. Our study explicitly shows that lifelong sports participation, especially of sprint-oriented nature, allows for maintaining a higher erythrocyte guanylate pool concentration, supporting cells’ energy metabolism, regulatory and transcription properties, and thus more efficient overall body functioning.Keywords: guanosine triphosphate, GTP, guanylate energy charge, GEC, purine metabolites, endurance, sprint, master athletes |
| first_indexed | 2024-03-13T01:50:52Z |
| format | Article |
| id | doaj.art-c1b46fefd7084ae78d3295eb37ffc4d7 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-03-13T01:50:52Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-c1b46fefd7084ae78d3295eb37ffc4d72023-07-02T19:49:15ZengDove Medical PressClinical Interventions in Aging1178-19982023-06-01Volume 1898799784635Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 YearsPospieszna BKusy KSlominska EMCiekot-Sołtysiak MZieliński JBarbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry, Medical University of Gdansk, Gdansk, PolandCorrespondence: Barbara Pospieszna, Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Królowej Jadwigi 27/39, Poznan, 61-871, Poland, Tel +48-618-355-270, Email bpospieszna@awf.poznan.plIntroduction: The guanine nucleotide pool (GTP, guanosine-5’-triphosphate; GDP, guanosine-5’-diphosphate, and GMP, guanosine-5’-monophosphate) is an essential energy donor in various biological processes (eg protein synthesis and gluconeogenesis) and secures several vital regulatory functions in the human body. The study aimed to predict the trends of age-related changes in erythrocyte guanine nucleotides and examine whether competitive sport and related physical training promote beneficial adaptations in erythrocyte guanylate concentrations.Methods: The study included 86 elite endurance runners (EN) aged 20– 81 years, 58 sprint-trained athletes (SP) aged 21– 90 years, and 62 untrained individuals (CO) aged 20– 68 years.Results: The concentration of erythrocyte GTP and total guanine nucleotides (TGN) were highest in the SP group, lower in the EN group, and lowest in the CO group. Both athletic groups had higher guanylate energy charge (GEC) values than the CO group (p = 0.012). Concentrations of GTP, TGN, and GEC value significantly decreased, while GDP and GMP concentrations progressively increased with age.Conclusion: Such a profile of change suggests a deterioration of the GTP-related regulatory function in older individuals. Our study explicitly shows that lifelong sports participation, especially of sprint-oriented nature, allows for maintaining a higher erythrocyte guanylate pool concentration, supporting cells’ energy metabolism, regulatory and transcription properties, and thus more efficient overall body functioning.Keywords: guanosine triphosphate, GTP, guanylate energy charge, GEC, purine metabolites, endurance, sprint, master athleteshttps://www.dovepress.com/sports-participation-promotes-beneficial-adaptations-in-the-erythrocyt-peer-reviewed-fulltext-article-CIAguanosine triphosphategtpguanylate energy chargegecpurine metabolitesendurancesprintmaster athletes |
| spellingShingle | Pospieszna B Kusy K Slominska EM Ciekot-Sołtysiak M Zieliński J Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years Clinical Interventions in Aging guanosine triphosphate gtp guanylate energy charge gec purine metabolites endurance sprint master athletes |
| title | Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years |
| title_full | Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years |
| title_fullStr | Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years |
| title_full_unstemmed | Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years |
| title_short | Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years |
| title_sort | sports participation promotes beneficial adaptations in the erythrocyte guanylate nucleotide pool in male athletes aged 20 ndash 90 years |
| topic | guanosine triphosphate gtp guanylate energy charge gec purine metabolites endurance sprint master athletes |
| url | https://www.dovepress.com/sports-participation-promotes-beneficial-adaptations-in-the-erythrocyt-peer-reviewed-fulltext-article-CIA |
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