Dual lipolytic control of body fat storage and mobilization in Drosophila.
Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lip...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-06-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.0050137 |
| _version_ | 1819109681911562240 |
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| author | Sebastian Grönke Günter Müller Jochen Hirsch Sonja Fellert Alexandra Andreou Tobias Haase Herbert Jäckle Ronald P Kühnlein |
| author_facet | Sebastian Grönke Günter Müller Jochen Hirsch Sonja Fellert Alexandra Andreou Tobias Haase Herbert Jäckle Ronald P Kühnlein |
| author_sort | Sebastian Grönke |
| collection | DOAJ |
| description | Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lipid droplets, and the various molecules and mechanisms guiding storage-fat mobilization, are conserved between mammals and insects. We generated a Drosophila mutant lacking the receptor (AKHR) of the adipokinetic hormone signaling pathway, an insect lipolytic pathway related to ss-adrenergic signaling in mammals. Combined genetic, physiological, and biochemical analyses provide in vivo evidence that AKHR is as important for chronic accumulation and acute mobilization of storage fat as is the Brummer lipase, the homolog of mammalian adipose triglyceride lipase (ATGL). Simultaneous loss of Brummer and AKHR causes extreme obesity and blocks acute storage-fat mobilization in flies. Our data demonstrate that storage-fat mobilization in the fly is coordinated by two lipocatabolic systems, which are essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis. |
| first_indexed | 2024-12-22T03:29:42Z |
| format | Article |
| id | doaj.art-c1b4a330f8b948eba1a92b49644359df |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-22T03:29:42Z |
| publishDate | 2007-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-c1b4a330f8b948eba1a92b49644359df2022-12-21T18:40:31ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852007-06-0156e13710.1371/journal.pbio.0050137Dual lipolytic control of body fat storage and mobilization in Drosophila.Sebastian GrönkeGünter MüllerJochen HirschSonja FellertAlexandra AndreouTobias HaaseHerbert JäckleRonald P KühnleinEnergy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lipid droplets, and the various molecules and mechanisms guiding storage-fat mobilization, are conserved between mammals and insects. We generated a Drosophila mutant lacking the receptor (AKHR) of the adipokinetic hormone signaling pathway, an insect lipolytic pathway related to ss-adrenergic signaling in mammals. Combined genetic, physiological, and biochemical analyses provide in vivo evidence that AKHR is as important for chronic accumulation and acute mobilization of storage fat as is the Brummer lipase, the homolog of mammalian adipose triglyceride lipase (ATGL). Simultaneous loss of Brummer and AKHR causes extreme obesity and blocks acute storage-fat mobilization in flies. Our data demonstrate that storage-fat mobilization in the fly is coordinated by two lipocatabolic systems, which are essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis.https://doi.org/10.1371/journal.pbio.0050137 |
| spellingShingle | Sebastian Grönke Günter Müller Jochen Hirsch Sonja Fellert Alexandra Andreou Tobias Haase Herbert Jäckle Ronald P Kühnlein Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biology |
| title | Dual lipolytic control of body fat storage and mobilization in Drosophila. |
| title_full | Dual lipolytic control of body fat storage and mobilization in Drosophila. |
| title_fullStr | Dual lipolytic control of body fat storage and mobilization in Drosophila. |
| title_full_unstemmed | Dual lipolytic control of body fat storage and mobilization in Drosophila. |
| title_short | Dual lipolytic control of body fat storage and mobilization in Drosophila. |
| title_sort | dual lipolytic control of body fat storage and mobilization in drosophila |
| url | https://doi.org/10.1371/journal.pbio.0050137 |
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