The Effects of Eprosartan on Cytoplasmic Free Calcium Mobilisation, Platelet Activation and Microparticle Formation in Hypertension. Could they be Relevant to Stroke Prevention?
The study examined a number of parameters of platelet function and activation in hypertensive patients compared with normotensive patients. It also examined the effects of the angiotensin receptor blocker eprosartan on these parameters. There were 30 patients with stage 1 or stage 2 hypertension plu...
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| Format: | Article |
| Language: | English |
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SAGE Publications
2005-03-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/14703203050060010101 |
| _version_ | 1797285419588517888 |
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| author | Marcial Martínez Silvestre |
| author_facet | Marcial Martínez Silvestre |
| author_sort | Marcial Martínez Silvestre |
| collection | DOAJ |
| description | The study examined a number of parameters of platelet function and activation in hypertensive patients compared with normotensive patients. It also examined the effects of the angiotensin receptor blocker eprosartan on these parameters. There were 30 patients with stage 1 or stage 2 hypertension plus 31 well-matched controls in this study. Phosphatidylserine, a measure of circulating activated platelets, was expressed more in hypertensive patients than in controls. Eprosartan partially corrected the enhanced platelet reactivity.There were greater numbers of activated platelet microparticles in hypertensive patients compared to controls. Again, eprosartan reduced this hyperproduction. Calcium kinetics of platelets were measured with flow cytometry using fluorescent markers.The free calcium concentration and its rise in response to thrombin were greater in hypertensive patients. Eprosartan significantly changed these parameters towards control values and reduced platelet activation. patients. Thus, eprosartan has the potential to reduce the risk of atherosclerotic events in hypertensive patients. |
| first_indexed | 2024-03-07T18:02:56Z |
| format | Article |
| id | doaj.art-c1b4ac6925a445bdaaf62ce7d538a030 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:02:56Z |
| publishDate | 2005-03-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-c1b4ac6925a445bdaaf62ce7d538a0302024-03-02T10:24:32ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762005-03-01610.1177/1470320305006001010110.1177_14703203050060010101The Effects of Eprosartan on Cytoplasmic Free Calcium Mobilisation, Platelet Activation and Microparticle Formation in Hypertension. Could they be Relevant to Stroke Prevention?Marcial Martínez SilvestreThe study examined a number of parameters of platelet function and activation in hypertensive patients compared with normotensive patients. It also examined the effects of the angiotensin receptor blocker eprosartan on these parameters. There were 30 patients with stage 1 or stage 2 hypertension plus 31 well-matched controls in this study. Phosphatidylserine, a measure of circulating activated platelets, was expressed more in hypertensive patients than in controls. Eprosartan partially corrected the enhanced platelet reactivity.There were greater numbers of activated platelet microparticles in hypertensive patients compared to controls. Again, eprosartan reduced this hyperproduction. Calcium kinetics of platelets were measured with flow cytometry using fluorescent markers.The free calcium concentration and its rise in response to thrombin were greater in hypertensive patients. Eprosartan significantly changed these parameters towards control values and reduced platelet activation. patients. Thus, eprosartan has the potential to reduce the risk of atherosclerotic events in hypertensive patients.https://doi.org/10.1177/14703203050060010101 |
| spellingShingle | Marcial Martínez Silvestre The Effects of Eprosartan on Cytoplasmic Free Calcium Mobilisation, Platelet Activation and Microparticle Formation in Hypertension. Could they be Relevant to Stroke Prevention? Journal of the Renin-Angiotensin-Aldosterone System |
| title | The Effects of Eprosartan on Cytoplasmic Free Calcium Mobilisation, Platelet Activation and Microparticle Formation in Hypertension. Could they be Relevant to Stroke Prevention? |
| title_full | The Effects of Eprosartan on Cytoplasmic Free Calcium Mobilisation, Platelet Activation and Microparticle Formation in Hypertension. Could they be Relevant to Stroke Prevention? |
| title_fullStr | The Effects of Eprosartan on Cytoplasmic Free Calcium Mobilisation, Platelet Activation and Microparticle Formation in Hypertension. Could they be Relevant to Stroke Prevention? |
| title_full_unstemmed | The Effects of Eprosartan on Cytoplasmic Free Calcium Mobilisation, Platelet Activation and Microparticle Formation in Hypertension. Could they be Relevant to Stroke Prevention? |
| title_short | The Effects of Eprosartan on Cytoplasmic Free Calcium Mobilisation, Platelet Activation and Microparticle Formation in Hypertension. Could they be Relevant to Stroke Prevention? |
| title_sort | effects of eprosartan on cytoplasmic free calcium mobilisation platelet activation and microparticle formation in hypertension could they be relevant to stroke prevention |
| url | https://doi.org/10.1177/14703203050060010101 |
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