Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis
BackgroundThe prognosis of several malignancies has been influenced by the systemic immune-inflammation index (SII); however, its association with the prognostic outcome of ovarian cancer (OC) remains controversial. The present meta-analysis focused on the systemic and comprehensive identification o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1193962/full |
| _version_ | 1827932929080164352 |
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| author | Huaying Mao Fan Yang |
| author_facet | Huaying Mao Fan Yang |
| author_sort | Huaying Mao |
| collection | DOAJ |
| description | BackgroundThe prognosis of several malignancies has been influenced by the systemic immune-inflammation index (SII); however, its association with the prognostic outcome of ovarian cancer (OC) remains controversial. The present meta-analysis focused on the systemic and comprehensive identification of the role of SII in predicting OC prognosis.MethodsWe searched the Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) from inception until March 6, 2023. To predict the prognostic value of SII for overall survival (OS) and progression-free survival (PFS) in patients with OC, we calculated pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).ResultsThe meta-analysis included six studies involving 1546 patients. The combined results showed that a high SII was significantly associated with poor OS (HR=2.70, 95% CI=1.98–3.67, p<0.001) and poor PFS (HR=2.71, 95% CI=1.78–4.12, p<0.001) in OC patients. These results were confirmed using subgroup and sensitivity analyses.ConclusionOur results concluded that a high SII significantly predicted poor OS and PFS in patients with OC. Therefore, it can be speculated that the SII may have an independent effect on the prognosis of OC. |
| first_indexed | 2024-03-13T07:17:25Z |
| format | Article |
| id | doaj.art-c1b4f988e7c3457cba222cbf1676232c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T07:17:25Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c1b4f988e7c3457cba222cbf1676232c2023-06-05T05:01:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11939621193962Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysisHuaying Mao0Fan Yang1Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, ChinaClinical Laboratory, Huzhou Maternity and Child Health Care Hospital, Huzhou, Zhejiang, ChinaBackgroundThe prognosis of several malignancies has been influenced by the systemic immune-inflammation index (SII); however, its association with the prognostic outcome of ovarian cancer (OC) remains controversial. The present meta-analysis focused on the systemic and comprehensive identification of the role of SII in predicting OC prognosis.MethodsWe searched the Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) from inception until March 6, 2023. To predict the prognostic value of SII for overall survival (OS) and progression-free survival (PFS) in patients with OC, we calculated pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).ResultsThe meta-analysis included six studies involving 1546 patients. The combined results showed that a high SII was significantly associated with poor OS (HR=2.70, 95% CI=1.98–3.67, p<0.001) and poor PFS (HR=2.71, 95% CI=1.78–4.12, p<0.001) in OC patients. These results were confirmed using subgroup and sensitivity analyses.ConclusionOur results concluded that a high SII significantly predicted poor OS and PFS in patients with OC. Therefore, it can be speculated that the SII may have an independent effect on the prognosis of OC.https://www.frontiersin.org/articles/10.3389/fonc.2023.1193962/fullSIIovarian cancermeta-analysisprognosissurvival |
| spellingShingle | Huaying Mao Fan Yang Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis Frontiers in Oncology SII ovarian cancer meta-analysis prognosis survival |
| title | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
| title_full | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
| title_fullStr | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
| title_full_unstemmed | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
| title_short | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
| title_sort | prognostic significance of systemic immune inflammation index in patients with ovarian cancer a meta analysis |
| topic | SII ovarian cancer meta-analysis prognosis survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1193962/full |
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