Is acute severe asthma a risk factor for the propofol infusion syndrome?
Propofol infusion syndrome (PRIS) is a rare but potentially fatal syndrome observed more commonly in young obese men receiving high dose (usually >4mg/kg/hr) or long term (>48 hrs) propofol. It can cause metabolic acidosis, renal failure, rhabdomyolysis, hyperkalemia, and cardiac failure. We r...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Southwest Respiratory and Critical Care Chronicles
2015-06-01
|
| Series: | Southwest Respiratory and Critical Care Chronicles |
| Subjects: | |
| Online Access: | http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/213 |
| Summary: | Propofol infusion syndrome (PRIS) is a rare but potentially fatal syndrome observed more commonly in young obese men receiving high dose (usually >4mg/kg/hr) or long term (>48 hrs) propofol. It can cause metabolic acidosis, renal failure, rhabdomyolysis, hyperkalemia, and cardiac failure. We report a case of possible PRIS in a 24-year-old obese Hispanic man admitted for acute severe asthma who developed PRIS in less than 12 hours on lower doses of propofol (3 mg/kg/hr tapered within 3 hrs) while on concurrent corticosteroids. Patients with acute asthma and subclinical myopathy may be at increased risk for propofol toxicity and need careful monitoring if this drug is used for sedation. |
|---|---|
| ISSN: | 2325-9205 |