Is acute severe asthma a risk factor for the propofol infusion syndrome?
Propofol infusion syndrome (PRIS) is a rare but potentially fatal syndrome observed more commonly in young obese men receiving high dose (usually >4mg/kg/hr) or long term (>48 hrs) propofol. It can cause metabolic acidosis, renal failure, rhabdomyolysis, hyperkalemia, and cardiac failure. We r...
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| Format: | Article |
| Language: | English |
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Southwest Respiratory and Critical Care Chronicles
2015-06-01
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| Series: | Southwest Respiratory and Critical Care Chronicles |
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| Online Access: | http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/213 |
| _version_ | 1819163148889882624 |
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| author | Avinash G Adiga Deepa Panikkath Hawa Edriss |
| author_facet | Avinash G Adiga Deepa Panikkath Hawa Edriss |
| author_sort | Avinash G Adiga |
| collection | DOAJ |
| description | Propofol infusion syndrome (PRIS) is a rare but potentially fatal syndrome observed more commonly in young obese men receiving high dose (usually >4mg/kg/hr) or long term (>48 hrs) propofol. It can cause metabolic acidosis, renal failure, rhabdomyolysis, hyperkalemia, and cardiac failure. We report a case of possible PRIS in a 24-year-old obese Hispanic man admitted for acute severe asthma who developed PRIS in less than 12 hours on lower doses of propofol (3 mg/kg/hr tapered within 3 hrs) while on concurrent corticosteroids. Patients with acute asthma and subclinical myopathy may be at increased risk for propofol toxicity and need careful monitoring if this drug is used for sedation. |
| first_indexed | 2024-12-22T17:39:32Z |
| format | Article |
| id | doaj.art-c1b556202f4645c68f88a42b13e27ac6 |
| institution | Directory Open Access Journal |
| issn | 2325-9205 |
| language | English |
| last_indexed | 2024-12-22T17:39:32Z |
| publishDate | 2015-06-01 |
| publisher | Southwest Respiratory and Critical Care Chronicles |
| record_format | Article |
| series | Southwest Respiratory and Critical Care Chronicles |
| spelling | doaj.art-c1b556202f4645c68f88a42b13e27ac62022-12-21T18:18:26ZengSouthwest Respiratory and Critical Care ChroniclesSouthwest Respiratory and Critical Care Chronicles2325-92052015-06-013114043194Is acute severe asthma a risk factor for the propofol infusion syndrome?Avinash G Adiga0Deepa PanikkathHawa EdrissDepartment of Internal Medicine, Texas Tech University Health Sciences CenterPropofol infusion syndrome (PRIS) is a rare but potentially fatal syndrome observed more commonly in young obese men receiving high dose (usually >4mg/kg/hr) or long term (>48 hrs) propofol. It can cause metabolic acidosis, renal failure, rhabdomyolysis, hyperkalemia, and cardiac failure. We report a case of possible PRIS in a 24-year-old obese Hispanic man admitted for acute severe asthma who developed PRIS in less than 12 hours on lower doses of propofol (3 mg/kg/hr tapered within 3 hrs) while on concurrent corticosteroids. Patients with acute asthma and subclinical myopathy may be at increased risk for propofol toxicity and need careful monitoring if this drug is used for sedation.http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/213propofolmetabolic acidosisrhabdomyolysisacute kidney injuryasthma |
| spellingShingle | Avinash G Adiga Deepa Panikkath Hawa Edriss Is acute severe asthma a risk factor for the propofol infusion syndrome? Southwest Respiratory and Critical Care Chronicles propofol metabolic acidosis rhabdomyolysis acute kidney injury asthma |
| title | Is acute severe asthma a risk factor for the propofol infusion syndrome? |
| title_full | Is acute severe asthma a risk factor for the propofol infusion syndrome? |
| title_fullStr | Is acute severe asthma a risk factor for the propofol infusion syndrome? |
| title_full_unstemmed | Is acute severe asthma a risk factor for the propofol infusion syndrome? |
| title_short | Is acute severe asthma a risk factor for the propofol infusion syndrome? |
| title_sort | is acute severe asthma a risk factor for the propofol infusion syndrome |
| topic | propofol metabolic acidosis rhabdomyolysis acute kidney injury asthma |
| url | http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/213 |
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