Durable responses in patients with HER2+ breast cancer and leptomeningeal metastases treated with trastuzumab deruxtecan
Abstract Leptomeningeal metastases (LM) are a devastating complication of HER2 + metastatic breast cancer (MBC), with no effective treatments. In a case series of 8 patients with heavily pretreated HER2 + MBC and progressing LM, all 8 patients (100%) derived clinical benefit from Trastuzumab deruxte...
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Bibliographic Details
| Main Authors: |
Laura Alder,
Dario Trapani,
Claire Bradbury,
Amanda E. D. Van Swearingen,
Sara M. Tolaney,
Mustafa Khasraw,
Carey K. Anders,
Christopher D. Lascola,
Liangge Hsu,
Nancy U. Lin,
Sarah Sammons |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-03-01
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| Series: | npj Breast Cancer
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| Online Access: | https://doi.org/10.1038/s41523-023-00519-0
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