Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8+ T cell

Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8+ T cell

Summary: Depletion of CD8+ T cells is a major obstacle in immunotherapy; however, the relevant mechanisms remain largely unknown. Here, we showed that prostate cancer (PCa) cell-derived exosomes hamper CD8+ T cell function by transporting interleukin-8 (IL-8). Compared to the low IL-8 levels detecte...

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Bibliographic Details
Main Authors: Fan Xu, Xiumei Wang, Ying Huang, Xiaoqian Zhang, Wenbo Sun, Yuanyuan Du, Zhi Xu, Hengyuan Kou, Shuyi Zhu, Caidong Liu, Xiaowei Wei, Xiao Li, Qin Jiang, Yong Xu
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723014365

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