Prime-Boost Vaccination With a Novel Hemagglutinin Protein Produced in Bacteria Induces Neutralizing Antibody Responses Against H5-Subtype Influenza Viruses in Commercial Chickens

Prime-Boost Vaccination With a Novel Hemagglutinin Protein Produced in Bacteria Induces Neutralizing Antibody Responses Against H5-Subtype Influenza Viruses in Commercial Chickens

The highly pathogenic (HP) avian influenza virus (AIV), H5N1 and reassortant H5-subtype HPAIVs, H5N2, H5N6, and H5N8, cause high mortality in domestic birds, resulting in economic losses in the poultry industry. H5N1 and H5N6 also pose significant public health risks and H5N1 viruses are a permanent...

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Bibliographic Details
Main Authors: Violetta Sączyńska, Agnieszka Romanik-Chruścielewska, Katarzyna Florys, Violetta Cecuda-Adamczewska, Natalia Łukasiewicz, Iwona Sokołowska, Małgorzata Kęsik-Brodacka, Grażyna Płucienniczak
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
influenza
H5-subtype influenza viruses
H5N1
hemagglutinin
recombinant vaccine
vaccination and immunization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02006/full

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