CLEC19A overexpression inhibits tumor cell proliferation/migration and promotes apoptosis concomitant suppression of PI3K/AKT/NF-κB signaling pathway in glioblastoma multiforme

CLEC19A overexpression inhibits tumor cell proliferation/migration and promotes apoptosis concomitant suppression of PI3K/AKT/NF-κB signaling pathway in glioblastoma multiforme

Abstract Background GBM is the most frequent malignant primary brain tumor in humans. The CLEC19A is a member of the C-type lectin family, which has a high expression in brain tissue. Herein, we sought to carry out an in-depth analysis to pinpoint the role of CLEC19A expression in GBM. Methods To de...

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Bibliographic Details
Main Authors: Fatemeh Mohajerani, Zahra Moazezi Tehrankhah, Saeid Rahmani, Nastaran Afsordeh, Sajad Shafiee, Mohammad Hossein Pourgholami, Bahram M. Soltani, Majid Sadeghizadeh
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Cancer
Subjects:
CLEC19A
C-type lectin
Glioblastoma
PI3K/AKT/NF-κB pathway
Tumor suppressor gene
Online Access:https://doi.org/10.1186/s12885-023-11755-9

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