The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies
(1) Introduction: Current evidence shows that mechanical debridement augmented with systemic and topical antibiotics may be beneficial for the treatment of peri-implantitis. The microbial profile of peri-implantitis plays a key role in identifying the most suitable antibiotics to be used for the tre...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/11/1610 |
| _version_ | 1797460423462617088 |
|---|---|
| author | Koay Chun Giok Rohit Kunnath Menon |
| author_facet | Koay Chun Giok Rohit Kunnath Menon |
| author_sort | Koay Chun Giok |
| collection | DOAJ |
| description | (1) Introduction: Current evidence shows that mechanical debridement augmented with systemic and topical antibiotics may be beneficial for the treatment of peri-implantitis. The microbial profile of peri-implantitis plays a key role in identifying the most suitable antibiotics to be used for the treatment and prevention of peri-implantitis. This systematic review aimed to summarize and critically analyze the methodology and findings of studies which have utilized sequencing techniques to elucidate the microbial profiles of peri-implantitis. (2) Results: <i>Fusobacterium, Treponema, and Porphyromonas</i> sp. are associated with peri-implantitis. <i>Veillonella</i> sp. are associated with healthy implant sites and exhibit a reduced prevalence in deeper pockets and with greater severity of disease progression. <i>Streptococcus</i> sp. have been identified both in diseased and healthy sites. <i>Neisseria</i> sp. have been associated with healthy implants and negatively correlate with the probing depth. Methanogens and AAGPRs were also detected in peri-implantitis sites. (3) Methods: The study was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023459266). The PRISMA criteria were used to select articles retrieved from a systematic search of the Scopus, Cochrane, and Medline databases until 1 August 2023. Title and abstract screening was followed by a full-text review of the included articles. Thirty-two articles were included in the final qualitative analysis. (4) Conclusions: A distinct microbial profile could not be identified from studies employing sequencing techniques to identify the microbiome. Further studies are needed with more standardization to allow a comparison of findings. A universal clinical parameter for the diagnosis of peri-implantitis should be implemented in all future studies to minimize confounding factors. The subject pool should also be more diverse and larger to compensate for individual differences, and perhaps a distinct microbial profile can be seen with a larger sample size. |
| first_indexed | 2024-03-09T17:04:52Z |
| format | Article |
| id | doaj.art-c1b9cb4f0c5d4cbd8096cad85f3cc5ee |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T17:04:52Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-c1b9cb4f0c5d4cbd8096cad85f3cc5ee2023-11-24T14:25:20ZengMDPI AGAntibiotics2079-63822023-11-011211161010.3390/antibiotics12111610The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing StudiesKoay Chun Giok0Rohit Kunnath Menon1School of Dentistry, International Medical University, Kuala Lumpur 57000, MalaysiaCollege of Dentistry, Ajman University, Ajman 346, United Arab Emirates(1) Introduction: Current evidence shows that mechanical debridement augmented with systemic and topical antibiotics may be beneficial for the treatment of peri-implantitis. The microbial profile of peri-implantitis plays a key role in identifying the most suitable antibiotics to be used for the treatment and prevention of peri-implantitis. This systematic review aimed to summarize and critically analyze the methodology and findings of studies which have utilized sequencing techniques to elucidate the microbial profiles of peri-implantitis. (2) Results: <i>Fusobacterium, Treponema, and Porphyromonas</i> sp. are associated with peri-implantitis. <i>Veillonella</i> sp. are associated with healthy implant sites and exhibit a reduced prevalence in deeper pockets and with greater severity of disease progression. <i>Streptococcus</i> sp. have been identified both in diseased and healthy sites. <i>Neisseria</i> sp. have been associated with healthy implants and negatively correlate with the probing depth. Methanogens and AAGPRs were also detected in peri-implantitis sites. (3) Methods: The study was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023459266). The PRISMA criteria were used to select articles retrieved from a systematic search of the Scopus, Cochrane, and Medline databases until 1 August 2023. Title and abstract screening was followed by a full-text review of the included articles. Thirty-two articles were included in the final qualitative analysis. (4) Conclusions: A distinct microbial profile could not be identified from studies employing sequencing techniques to identify the microbiome. Further studies are needed with more standardization to allow a comparison of findings. A universal clinical parameter for the diagnosis of peri-implantitis should be implemented in all future studies to minimize confounding factors. The subject pool should also be more diverse and larger to compensate for individual differences, and perhaps a distinct microbial profile can be seen with a larger sample size.https://www.mdpi.com/2079-6382/12/11/1610peri-implantitismicrobiomesequencingdental implantcomplications |
| spellingShingle | Koay Chun Giok Rohit Kunnath Menon The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies Antibiotics peri-implantitis microbiome sequencing dental implant complications |
| title | The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies |
| title_full | The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies |
| title_fullStr | The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies |
| title_full_unstemmed | The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies |
| title_short | The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies |
| title_sort | microbiome of peri implantitis a systematic review of next generation sequencing studies |
| topic | peri-implantitis microbiome sequencing dental implant complications |
| url | https://www.mdpi.com/2079-6382/12/11/1610 |
| work_keys_str_mv | AT koaychungiok themicrobiomeofperiimplantitisasystematicreviewofnextgenerationsequencingstudies AT rohitkunnathmenon themicrobiomeofperiimplantitisasystematicreviewofnextgenerationsequencingstudies AT koaychungiok microbiomeofperiimplantitisasystematicreviewofnextgenerationsequencingstudies AT rohitkunnathmenon microbiomeofperiimplantitisasystematicreviewofnextgenerationsequencingstudies |