Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

Aims/hypothesis: The adipose tissue-derived hormone leptin plays an important role in the maintenance of body weight and glucose homeostasis. Leptin mediates its effects by interaction with leptin receptors (LepRb), which are highly expressed in the hypothalamus and other brain centres, and at lower...

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Bibliographic Details
Main Authors: Helen Soedling, David J. Hodson, Alice E. Adrianssens, Fiona M. Gribble, Frank Reimann, Stefan Trapp, Guy A. Rutter
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Molecular Metabolism
Subjects:
Leptin
Insulin
Glucagon
GLP-1
Diabetes
β cell
α cell
L-cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001209

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