Agreement Between QuantiFERON-TB Gold In-tube and Tuberculin Skin Tests in Hematopoietic Stem Cell Transplantation Candidates
Introduction: Malignancies are among the most important risk factors for progression of latent tuberculosis (TB) to active disease. The tuberculin skin test (TST) has been used worldwide for the diagnosis of latent TB. New T-cell-based interferon-gamma release assays such as QuantiFERON-TB Gold In-T...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Turkish |
| Published: |
Galenos Yayinevi
2019-12-01
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| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| Subjects: | |
| Online Access: | http://mjima.org/text.php?&id=176 |
| _version_ | 1797923196621553664 |
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| author | Gülşen İSKENDER Göknur YAPAR TOROS Sabahat ÇEKEN Figen SEZEN Habip GEDİK Mehmet Sinan DAL Mustafa ERTEK |
| author_facet | Gülşen İSKENDER Göknur YAPAR TOROS Sabahat ÇEKEN Figen SEZEN Habip GEDİK Mehmet Sinan DAL Mustafa ERTEK |
| author_sort | Gülşen İSKENDER |
| collection | DOAJ |
| description | Introduction: Malignancies are among the most important risk factors for progression of latent tuberculosis (TB) to active disease. The tuberculin skin test (TST) has been used worldwide for the diagnosis of latent TB. New T-cell-based interferon-gamma release assays such as QuantiFERON-TB Gold In-Tube (QFT-GIT) have yielded promising results in this regard, but little information is available on their use in hematopoietic stem cell recipients. The aim of this study was to evaluate the agreement between QFT-GIT and TST in the diagnosis of latent TB in hematopoietic stem cell transplantation (HSCT) candidates.
Materials and Methods: Patients who underwent HSCT in our hospital between November 1, 2013 and July 31, 2015 were retrospectively evaluated from patient files. Those who had both QFT-GIT and TST before transplantation were included in the study. Isoniazid prophylaxis was initiated one week before transplantation and continued for nine months for patients with positive results in one or both tests. The kappa (κ) coefficients were calculated to analyze the agreement between two tests.
Results: The study included 122 patients, (53.3% autologous and 46.7% allogeneic hematopoietic stem cell recipients). The median age was 43.5 years (25-75% IQR: 30-54) and 73% were men. Bacillus Calmette-Guérin (BCG) scars were seen in 84.4% of the patients. Tuberculin skin test and QFT-GIT test were positive in 38 (31.1%) and 26 (21.3%) of the patients, respectively. Both TST and QFT-GIT were positive in 17 patients (13.9%). There was no statistically significant relationship between the two tests and BCG scars. Statistically significant, fair agreement was found between positive TST and QFT-GIT results (κ=0.37 and p<0.001). Patients were followed until July 2018. The median follow-up time of all patients was 39 months (IQR: 10.8-49.0). None of the patients developed active TB during follow-up, but 44.3% of the patients died due to malignancy and/or opportunistic infections.
Conclusion: Further research is needed to demonstrate the agreement between these two tests in the diagnosis of latent TB in HSCT patients. For now, the combination of these two tests seems to be most rational for these patients. |
| first_indexed | 2024-04-10T14:42:58Z |
| format | Article |
| id | doaj.art-c1ba6d361d9043e0810049655331e216 |
| institution | Directory Open Access Journal |
| issn | 2147-673X |
| language | Turkish |
| last_indexed | 2024-04-10T14:42:58Z |
| publishDate | 2019-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj.art-c1ba6d361d9043e0810049655331e2162023-02-15T16:08:06ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2019-12-01810.4274/mjima.galenos.2019.2019.20Agreement Between QuantiFERON-TB Gold In-tube and Tuberculin Skin Tests in Hematopoietic Stem Cell Transplantation CandidatesGülşen İSKENDER0https://orcid.org/0000-0001-7619-1366Göknur YAPAR TOROS1https://orcid.org/0000-0001-8256-0666Sabahat ÇEKEN2https://orcid.org/0000-0002-3679-0978Figen SEZEN3https://orcid.org/0000-0002-9282-1070Habip GEDİK4https://orcid.org/0000-0002-8406-2254Mehmet Sinan DAL5https://orcid.org/0000-0002-5994-2735Mustafa ERTEK6https://orcid.org/0000-0002-9397-8432University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Ankara, TurkeyUniversity of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Ankara, TurkeyUniversity of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Ankara, TurkeyRepublic of Turkey Ministry of Health, General Directorate of Public Health, Health Threats Early Warning and Response Department, Ankara, Turkeyİstanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, İstanbul, TurkeyUniversity of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Clinic of Hematology, Blood and Marrow Transplantation, Ankara, TurkeyUniversity of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Ankara, TurkeyIntroduction: Malignancies are among the most important risk factors for progression of latent tuberculosis (TB) to active disease. The tuberculin skin test (TST) has been used worldwide for the diagnosis of latent TB. New T-cell-based interferon-gamma release assays such as QuantiFERON-TB Gold In-Tube (QFT-GIT) have yielded promising results in this regard, but little information is available on their use in hematopoietic stem cell recipients. The aim of this study was to evaluate the agreement between QFT-GIT and TST in the diagnosis of latent TB in hematopoietic stem cell transplantation (HSCT) candidates. Materials and Methods: Patients who underwent HSCT in our hospital between November 1, 2013 and July 31, 2015 were retrospectively evaluated from patient files. Those who had both QFT-GIT and TST before transplantation were included in the study. Isoniazid prophylaxis was initiated one week before transplantation and continued for nine months for patients with positive results in one or both tests. The kappa (κ) coefficients were calculated to analyze the agreement between two tests. Results: The study included 122 patients, (53.3% autologous and 46.7% allogeneic hematopoietic stem cell recipients). The median age was 43.5 years (25-75% IQR: 30-54) and 73% were men. Bacillus Calmette-Guérin (BCG) scars were seen in 84.4% of the patients. Tuberculin skin test and QFT-GIT test were positive in 38 (31.1%) and 26 (21.3%) of the patients, respectively. Both TST and QFT-GIT were positive in 17 patients (13.9%). There was no statistically significant relationship between the two tests and BCG scars. Statistically significant, fair agreement was found between positive TST and QFT-GIT results (κ=0.37 and p<0.001). Patients were followed until July 2018. The median follow-up time of all patients was 39 months (IQR: 10.8-49.0). None of the patients developed active TB during follow-up, but 44.3% of the patients died due to malignancy and/or opportunistic infections. Conclusion: Further research is needed to demonstrate the agreement between these two tests in the diagnosis of latent TB in HSCT patients. For now, the combination of these two tests seems to be most rational for these patients.http://mjima.org/text.php?&id=176preventive medicinepurified protein derivative testprophylaxiscorrelation analysismycobacterium tuberculosis |
| spellingShingle | Gülşen İSKENDER Göknur YAPAR TOROS Sabahat ÇEKEN Figen SEZEN Habip GEDİK Mehmet Sinan DAL Mustafa ERTEK Agreement Between QuantiFERON-TB Gold In-tube and Tuberculin Skin Tests in Hematopoietic Stem Cell Transplantation Candidates Mediterranean Journal of Infection, Microbes and Antimicrobials preventive medicine purified protein derivative test prophylaxis correlation analysis mycobacterium tuberculosis |
| title | Agreement Between QuantiFERON-TB Gold In-tube and Tuberculin Skin Tests in Hematopoietic Stem Cell Transplantation Candidates |
| title_full | Agreement Between QuantiFERON-TB Gold In-tube and Tuberculin Skin Tests in Hematopoietic Stem Cell Transplantation Candidates |
| title_fullStr | Agreement Between QuantiFERON-TB Gold In-tube and Tuberculin Skin Tests in Hematopoietic Stem Cell Transplantation Candidates |
| title_full_unstemmed | Agreement Between QuantiFERON-TB Gold In-tube and Tuberculin Skin Tests in Hematopoietic Stem Cell Transplantation Candidates |
| title_short | Agreement Between QuantiFERON-TB Gold In-tube and Tuberculin Skin Tests in Hematopoietic Stem Cell Transplantation Candidates |
| title_sort | agreement between quantiferon tb gold in tube and tuberculin skin tests in hematopoietic stem cell transplantation candidates |
| topic | preventive medicine purified protein derivative test prophylaxis correlation analysis mycobacterium tuberculosis |
| url | http://mjima.org/text.php?&id=176 |
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