Revealing the clinical effect and biological mechanism of acupuncture in COPD: A review
Background: To provide new ideas for the clinical and mechanism research of acupuncture in the treatment of chronic obstructive pulmonary disease (COPD), this study systematically reviews clinical research and the progress of basic research of acupuncture in the treatment of COPD. Methods: PubMed an...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223017249 |
| _version_ | 1797364323211804672 |
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| author | Fangyuan Shi Jiaojiao Cao Dan Zhou Xue Wang Haitao Yang Tingting Liu Zhihan Chen Jiaming Zeng Simin Du Lin Yang Ruo Jia Siqi Zhang Mingxing Zhang Yi Guo Xiaowei Lin |
| author_facet | Fangyuan Shi Jiaojiao Cao Dan Zhou Xue Wang Haitao Yang Tingting Liu Zhihan Chen Jiaming Zeng Simin Du Lin Yang Ruo Jia Siqi Zhang Mingxing Zhang Yi Guo Xiaowei Lin |
| author_sort | Fangyuan Shi |
| collection | DOAJ |
| description | Background: To provide new ideas for the clinical and mechanism research of acupuncture in the treatment of chronic obstructive pulmonary disease (COPD), this study systematically reviews clinical research and the progress of basic research of acupuncture in the treatment of COPD. Methods: PubMed and Web of Science databases were searched using acupuncture and COPD as keywords in the last 10 years, and the included literature was determined according to exclusion criteria. Findings: Acupuncture can relieve clinical symptoms, improve exercise tolerance, anxiety, and nutritional status, as well as hemorheological changes (blood viscosity), reduce the inflammatory response, and reduce the duration and frequency of COPD in patients with COPD. Mechanistically, acupuncture inhibits M1 macrophage activity, reduces neutrophil infiltration, reduces inflammatory factor production in alveolar type II epithelial cells, inhibits mucus hypersecretion of airway epithelial cells, inhibits the development of chronic inflammation in COPD, and slows tissue structure destruction. Acupuncture may control pulmonary COPD inflammation through the vagal-cholinergic anti-inflammatory, vagal-adrenomedullary-dopamine, vagal-dual-sensory nerve fiber-pulmonary, and CNS-hypothalamus-orexin pathways. Furthermore, acupuncture can increase endogenous cortisol levels by inhibiting the HPA axis, thus improving airway antioxidant capacity and reducing airway inflammation in COPD. In conclusion, the inhibition of the chronic inflammatory response is the key mechanism of acupuncture treatment for COPD. |
| first_indexed | 2024-03-08T16:33:36Z |
| format | Article |
| id | doaj.art-c1bb223db6c44160a0ba4aac2eff6106 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:33:36Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-c1bb223db6c44160a0ba4aac2eff61062024-01-06T04:37:36ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170115926Revealing the clinical effect and biological mechanism of acupuncture in COPD: A reviewFangyuan Shi0Jiaojiao Cao1Dan Zhou2Xue Wang3Haitao Yang4Tingting Liu5Zhihan Chen6Jiaming Zeng7Simin Du8Lin Yang9Ruo Jia10Siqi Zhang11Mingxing Zhang12Yi Guo13Xiaowei Lin14Tianjin Key Laboratory of Modern Chinese Medicine Theory of Innovation and Application, School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Research Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaResearch Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaTianjin Key Laboratory of Modern Chinese Medicine Theory of Innovation and Application, School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaMinistry of Education, and State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, ChinaSchool of Intergrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Corresponding authors.Research Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Corresponding authors.Tianjin Key Laboratory of Modern Chinese Medicine Theory of Innovation and Application, School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Research Center of Experimental Acupuncture Science, School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Corresponding author at: Tianjin Key Laboratory of Modern Chinese Medicine Theory of Innovation and Application, School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.Background: To provide new ideas for the clinical and mechanism research of acupuncture in the treatment of chronic obstructive pulmonary disease (COPD), this study systematically reviews clinical research and the progress of basic research of acupuncture in the treatment of COPD. Methods: PubMed and Web of Science databases were searched using acupuncture and COPD as keywords in the last 10 years, and the included literature was determined according to exclusion criteria. Findings: Acupuncture can relieve clinical symptoms, improve exercise tolerance, anxiety, and nutritional status, as well as hemorheological changes (blood viscosity), reduce the inflammatory response, and reduce the duration and frequency of COPD in patients with COPD. Mechanistically, acupuncture inhibits M1 macrophage activity, reduces neutrophil infiltration, reduces inflammatory factor production in alveolar type II epithelial cells, inhibits mucus hypersecretion of airway epithelial cells, inhibits the development of chronic inflammation in COPD, and slows tissue structure destruction. Acupuncture may control pulmonary COPD inflammation through the vagal-cholinergic anti-inflammatory, vagal-adrenomedullary-dopamine, vagal-dual-sensory nerve fiber-pulmonary, and CNS-hypothalamus-orexin pathways. Furthermore, acupuncture can increase endogenous cortisol levels by inhibiting the HPA axis, thus improving airway antioxidant capacity and reducing airway inflammation in COPD. In conclusion, the inhibition of the chronic inflammatory response is the key mechanism of acupuncture treatment for COPD.http://www.sciencedirect.com/science/article/pii/S0753332223017249AcupunctureCOPDClinical treatmentMechanism |
| spellingShingle | Fangyuan Shi Jiaojiao Cao Dan Zhou Xue Wang Haitao Yang Tingting Liu Zhihan Chen Jiaming Zeng Simin Du Lin Yang Ruo Jia Siqi Zhang Mingxing Zhang Yi Guo Xiaowei Lin Revealing the clinical effect and biological mechanism of acupuncture in COPD: A review Biomedicine & Pharmacotherapy Acupuncture COPD Clinical treatment Mechanism |
| title | Revealing the clinical effect and biological mechanism of acupuncture in COPD: A review |
| title_full | Revealing the clinical effect and biological mechanism of acupuncture in COPD: A review |
| title_fullStr | Revealing the clinical effect and biological mechanism of acupuncture in COPD: A review |
| title_full_unstemmed | Revealing the clinical effect and biological mechanism of acupuncture in COPD: A review |
| title_short | Revealing the clinical effect and biological mechanism of acupuncture in COPD: A review |
| title_sort | revealing the clinical effect and biological mechanism of acupuncture in copd a review |
| topic | Acupuncture COPD Clinical treatment Mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223017249 |
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