Incidence of herpes simplex virus type 2 in young reproductive age women in Mysore, India
Context: There are sparse data on herpes simplex virus type 2 (HSV-2) infection in India. HSV-2 is one of the most common sexually transmitted infections and the primary cause of genital ulcer disease worldwide. Aim: The aim of this study is to describe the incidence of HSV-2 infection among young r...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=96;epage=99;aulast=Madhivanan |
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| author | Purnima Madhivanan Yea-Hung Chen Karl Krupp Anjali Arun Jeffrey D Klausner Arthur L Reingold |
| author_facet | Purnima Madhivanan Yea-Hung Chen Karl Krupp Anjali Arun Jeffrey D Klausner Arthur L Reingold |
| author_sort | Purnima Madhivanan |
| collection | DOAJ |
| description | Context: There are sparse data on herpes simplex virus type 2 (HSV-2) infection in India. HSV-2 is one of the most common sexually transmitted infections and the primary cause of genital ulcer disease worldwide. Aim: The aim of this study is to describe the incidence of HSV-2 infection among young reproductive age women in Mysore, India. Setting and Design: Between October 2005 and April 2006, 898 women were enrolled into a prospective cohort study in Mysore, India, and followed quarterly for 6 months. Materials and Methods: An interviewer administered questionnaire was used to collect demographic and social risk factors, and physical examination was conducted for collection of biological specimens to screen for reproductive tract infections at each visit. Serologic testing was conducted for the presence of HSV-2 antibodies using HerpeSelect HSV-2 enzyme-linked immunosorbent assay. Statistical Analysis Used: Data were analyzed using R. Incidence density rates were calculated using Poisson distributions with person-time of follow-up as denominator. Person-time was calculated as time from enrollment until time of first positive HSV-2 test. Results: There were 107 women with HSV-2 antibodies leaving 700 women with negative results at enrollment. The analysis included 696 out of which, there were 36 HSV-2 seroconversions during the study period. The study cohort accumulated roughly 348 woman-years of follow-up, yielding an HSV-2 acquisition rate of 10.4 cases/100 woman-years. All detected infections were asymptomatic. Conclusions: HSV-2 incidence is moderate in this community sample of young reproductive age monogamous women. More research is needed to establish incidence estimates in different Indian settings. |
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| id | doaj.art-c1bb3369ea2f4bf9970b7e03b71b412c |
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| issn | 0377-4929 |
| language | English |
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| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-c1bb3369ea2f4bf9970b7e03b71b412c2022-12-21T18:58:16ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292011-01-01541969910.4103/0377-4929.77336Incidence of herpes simplex virus type 2 in young reproductive age women in Mysore, IndiaPurnima MadhivananYea-Hung ChenKarl KruppAnjali ArunJeffrey D KlausnerArthur L ReingoldContext: There are sparse data on herpes simplex virus type 2 (HSV-2) infection in India. HSV-2 is one of the most common sexually transmitted infections and the primary cause of genital ulcer disease worldwide. Aim: The aim of this study is to describe the incidence of HSV-2 infection among young reproductive age women in Mysore, India. Setting and Design: Between October 2005 and April 2006, 898 women were enrolled into a prospective cohort study in Mysore, India, and followed quarterly for 6 months. Materials and Methods: An interviewer administered questionnaire was used to collect demographic and social risk factors, and physical examination was conducted for collection of biological specimens to screen for reproductive tract infections at each visit. Serologic testing was conducted for the presence of HSV-2 antibodies using HerpeSelect HSV-2 enzyme-linked immunosorbent assay. Statistical Analysis Used: Data were analyzed using R. Incidence density rates were calculated using Poisson distributions with person-time of follow-up as denominator. Person-time was calculated as time from enrollment until time of first positive HSV-2 test. Results: There were 107 women with HSV-2 antibodies leaving 700 women with negative results at enrollment. The analysis included 696 out of which, there were 36 HSV-2 seroconversions during the study period. The study cohort accumulated roughly 348 woman-years of follow-up, yielding an HSV-2 acquisition rate of 10.4 cases/100 woman-years. All detected infections were asymptomatic. Conclusions: HSV-2 incidence is moderate in this community sample of young reproductive age monogamous women. More research is needed to establish incidence estimates in different Indian settings.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=96;epage=99;aulast=MadhivananHerpes simplex virusherpes simplex virus type 2incidenceIndiaWomen |
| spellingShingle | Purnima Madhivanan Yea-Hung Chen Karl Krupp Anjali Arun Jeffrey D Klausner Arthur L Reingold Incidence of herpes simplex virus type 2 in young reproductive age women in Mysore, India Indian Journal of Pathology and Microbiology Herpes simplex virus herpes simplex virus type 2 incidence India Women |
| title | Incidence of herpes simplex virus type 2 in young reproductive age women in Mysore, India |
| title_full | Incidence of herpes simplex virus type 2 in young reproductive age women in Mysore, India |
| title_fullStr | Incidence of herpes simplex virus type 2 in young reproductive age women in Mysore, India |
| title_full_unstemmed | Incidence of herpes simplex virus type 2 in young reproductive age women in Mysore, India |
| title_short | Incidence of herpes simplex virus type 2 in young reproductive age women in Mysore, India |
| title_sort | incidence of herpes simplex virus type 2 in young reproductive age women in mysore india |
| topic | Herpes simplex virus herpes simplex virus type 2 incidence India Women |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=96;epage=99;aulast=Madhivanan |
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