Fluorine-Functionalized Polyphosphazene Immunoadjuvant: Synthesis, Solution Behavior and In Vivo Potency
The inclusion of fluorine motifs in drugs and drug delivery systems is an established tool for modulating their biological potency. Fluorination can improve drug specificity or boost the vehicle’s ability to cross cellular membranes. However, the approach has yet to be applied to vaccine adjuvants....
Main Authors: | Harichandra D. Tagad, Alexander Marin, Ruixue Wang, Abdul S. Yunus, Thomas R. Fuerst, Alexander K. Andrianov |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-05-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/28/10/4218 |
Similar Items
-
Skin Vaccination with Ebola Virus Glycoprotein Using a Polyphosphazene-Based Microneedle Patch Protects Mice against Lethal Challenge
by: Andrey Romanyuk, et al.
Published: (2022-12-01) -
Chemistry and applications of polyphosphazenes /
by: 265348 Allcock, Harry R.
Published: (2003) -
Virus-Mimicking Polymer Nanocomplexes Co-Assembling HCV E1E2 and Core Proteins with TLR 7/8 Agonist—Synthesis, Characterization, and In Vivo Activity
by: Thomas R. Fuerst, et al.
Published: (2025-01-01) -
Intracellular Delivery of Active Proteins by Polyphosphazene Polymers
by: Bareera Qamar, et al.
Published: (2021-02-01) -
Self-assembly of polyphosphazene immunoadjuvant with poly(ethylene oxide) enables advanced nanoscale delivery modalities and regulated pH-dependent cellular membrane activity
by: Alexander K. Andrianov, et al.
Published: (2016-04-01)