Endothelial dysfunction role in atherosclerosis pathogenesis
According to modern views, the key component in atherosclerosis pathogenesis is endothelial dysfunction (ED), manifesting in dysbalance between main endothelial functions: vasodilatation and vasoconstriction, proliferation inhibition and promotion, antithrombotic and prothrombotic, antioxidant and p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2006-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1415 |
| _version_ | 1797882762047258624 |
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| author | E. N. Vorobyeva G. I. Shumakher I. V. Osipova M. A. Khoreva R. I. Vorobyev |
| author_facet | E. N. Vorobyeva G. I. Shumakher I. V. Osipova M. A. Khoreva R. I. Vorobyev |
| author_sort | E. N. Vorobyeva |
| collection | DOAJ |
| description | According to modern views, the key component in atherosclerosis pathogenesis is endothelial dysfunction (ED), manifesting in dysbalance between main endothelial functions: vasodilatation and vasoconstriction, proliferation inhibition and promotion, antithrombotic and prothrombotic, antioxidant and prooxidant functions. Endothelial effects are mediated through vasoactive agents’ release – vasodilatators (NO, prostacyclin, bradykinin) and vasoconstrictors (endothelin, free oxygen radicals, thromboxan A2 , angiotensin II). It has been demonstrated that virtually all atherosclerosis risk factors (RF) realize their negative effects via ED. Therefore, endothelial function parameters could be used as early atherosclerosis markers in individuals with atherosclerosis RF, at pre-clinical stage. Pathogenetic therapy, administered early or in already verified atherosclerosis, could improve patients’ prognosis substantially. |
| first_indexed | 2024-04-10T03:40:54Z |
| format | Article |
| id | doaj.art-c1bc252383304bb99023d1433f4ebefa |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:40:54Z |
| publishDate | 2006-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-c1bc252383304bb99023d1433f4ebefa2023-03-13T07:23:13Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252006-12-01561291361125Endothelial dysfunction role in atherosclerosis pathogenesisE. N. Vorobyeva0G. I. Shumakher1I. V. Osipova2M. A. Khoreva3R. I. Vorobyev4Алтайский государственный медицинский университет. БарнаулАлтайский государственный медицинский университет. БарнаулАлтайский государственный медицинский университет. БарнаулАлтайский государственный медицинский университет. БарнаулАлтайский государственный медицинский университет. БарнаулAccording to modern views, the key component in atherosclerosis pathogenesis is endothelial dysfunction (ED), manifesting in dysbalance between main endothelial functions: vasodilatation and vasoconstriction, proliferation inhibition and promotion, antithrombotic and prothrombotic, antioxidant and prooxidant functions. Endothelial effects are mediated through vasoactive agents’ release – vasodilatators (NO, prostacyclin, bradykinin) and vasoconstrictors (endothelin, free oxygen radicals, thromboxan A2 , angiotensin II). It has been demonstrated that virtually all atherosclerosis risk factors (RF) realize their negative effects via ED. Therefore, endothelial function parameters could be used as early atherosclerosis markers in individuals with atherosclerosis RF, at pre-clinical stage. Pathogenetic therapy, administered early or in already verified atherosclerosis, could improve patients’ prognosis substantially.https://cardiovascular.elpub.ru/jour/article/view/1415атеросклероздисфункция эндотелияфакторы рискаэндотелиноксид азота |
| spellingShingle | E. N. Vorobyeva G. I. Shumakher I. V. Osipova M. A. Khoreva R. I. Vorobyev Endothelial dysfunction role in atherosclerosis pathogenesis Кардиоваскулярная терапия и профилактика атеросклероз дисфункция эндотелия факторы риска эндотелин оксид азота |
| title | Endothelial dysfunction role in atherosclerosis pathogenesis |
| title_full | Endothelial dysfunction role in atherosclerosis pathogenesis |
| title_fullStr | Endothelial dysfunction role in atherosclerosis pathogenesis |
| title_full_unstemmed | Endothelial dysfunction role in atherosclerosis pathogenesis |
| title_short | Endothelial dysfunction role in atherosclerosis pathogenesis |
| title_sort | endothelial dysfunction role in atherosclerosis pathogenesis |
| topic | атеросклероз дисфункция эндотелия факторы риска эндотелин оксид азота |
| url | https://cardiovascular.elpub.ru/jour/article/view/1415 |
| work_keys_str_mv | AT envorobyeva endothelialdysfunctionroleinatherosclerosispathogenesis AT gishumakher endothelialdysfunctionroleinatherosclerosispathogenesis AT ivosipova endothelialdysfunctionroleinatherosclerosispathogenesis AT makhoreva endothelialdysfunctionroleinatherosclerosispathogenesis AT rivorobyev endothelialdysfunctionroleinatherosclerosispathogenesis |