High blood viscosity in acute ischemic stroke
BackgroundThe changes in blood viscosity can influence the shear stress at the vessel wall, but there is limited evidence regarding the impact on thrombogenesis and acute stroke. We aimed to investigate the effect of blood viscosity on stroke and the clinical utility of blood viscosity measurements...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1320773/full |
| _version_ | 1827620523208605696 |
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| author | Jihoon Kang Ju Seok Oh Beom Joon Kim Jun Yup Kim Do Yeon Kim So-Yeon Yun Moon-Ku Han Hee-Joon Bae Inwon Park Jae Hyuk Lee You Hwan Jo Kyung Hyun Ahn |
| author_facet | Jihoon Kang Ju Seok Oh Beom Joon Kim Jun Yup Kim Do Yeon Kim So-Yeon Yun Moon-Ku Han Hee-Joon Bae Inwon Park Jae Hyuk Lee You Hwan Jo Kyung Hyun Ahn |
| author_sort | Jihoon Kang |
| collection | DOAJ |
| description | BackgroundThe changes in blood viscosity can influence the shear stress at the vessel wall, but there is limited evidence regarding the impact on thrombogenesis and acute stroke. We aimed to investigate the effect of blood viscosity on stroke and the clinical utility of blood viscosity measurements obtained immediately upon hospital arrival.MethodsPatients with suspected stroke visiting the hospital within 24 h of the last known well time were enrolled. Point-of-care testing was used to obtain blood viscosity measurements before intravenous fluid infusion. Blood viscosity was measured as the reactive torque generated at three oscillatory frequencies (1, 5, and 10 rad/sec). Blood viscosity results were compared among patients with ischemic stroke, hemorrhagic stroke, and stroke mimics diagnosed as other than stroke.ResultsAmong 112 enrolled patients, blood viscosity measurements were accomplished within 2.4 ± 1.3 min of vessel puncture. At an oscillatory frequency of 10 rad/sec, blood viscosity differed significantly between the ischemic stroke (24.2 ± 4.9 centipoise, cP) and stroke mimic groups (17.8 ± 6.5 cP, p < 0.001). This finding was consistent at different oscillatory frequencies (134.2 ± 46.3 vs. 102.4 ± 47.2 at 1 rad/sec and 39.2 ± 11.5 vs. 30.4 ± 12.4 at 5 rad/sec, Ps < 0.001), suggesting a relationship between decreases in viscosity and shear rate. The area under the receiver operating curve for differentiating cases of stroke from stroke mimic was 0.79 (95% confidence interval, 0.69–0.88).ConclusionPatients with ischemic stroke exhibit increases in whole blood viscosity, suggesting that blood viscosity measurements can aid in differentiating ischemic stroke from other diseases. |
| first_indexed | 2024-03-09T10:49:19Z |
| format | Article |
| id | doaj.art-c1bccb29b5c44726ba314996f034628d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-09T10:49:19Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c1bccb29b5c44726ba314996f034628d2023-12-01T09:36:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-11-011410.3389/fneur.2023.13207731320773High blood viscosity in acute ischemic strokeJihoon Kang0Ju Seok Oh1Beom Joon Kim2Jun Yup Kim3Do Yeon Kim4So-Yeon Yun5Moon-Ku Han6Hee-Joon Bae7Inwon Park8Jae Hyuk Lee9You Hwan Jo10Kyung Hyun Ahn11Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Advanced Materials and Chemical Engineering, Hannam University, Daejeon, Republic of KoreaDepartment of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaSchool of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Republic of KoreaBackgroundThe changes in blood viscosity can influence the shear stress at the vessel wall, but there is limited evidence regarding the impact on thrombogenesis and acute stroke. We aimed to investigate the effect of blood viscosity on stroke and the clinical utility of blood viscosity measurements obtained immediately upon hospital arrival.MethodsPatients with suspected stroke visiting the hospital within 24 h of the last known well time were enrolled. Point-of-care testing was used to obtain blood viscosity measurements before intravenous fluid infusion. Blood viscosity was measured as the reactive torque generated at three oscillatory frequencies (1, 5, and 10 rad/sec). Blood viscosity results were compared among patients with ischemic stroke, hemorrhagic stroke, and stroke mimics diagnosed as other than stroke.ResultsAmong 112 enrolled patients, blood viscosity measurements were accomplished within 2.4 ± 1.3 min of vessel puncture. At an oscillatory frequency of 10 rad/sec, blood viscosity differed significantly between the ischemic stroke (24.2 ± 4.9 centipoise, cP) and stroke mimic groups (17.8 ± 6.5 cP, p < 0.001). This finding was consistent at different oscillatory frequencies (134.2 ± 46.3 vs. 102.4 ± 47.2 at 1 rad/sec and 39.2 ± 11.5 vs. 30.4 ± 12.4 at 5 rad/sec, Ps < 0.001), suggesting a relationship between decreases in viscosity and shear rate. The area under the receiver operating curve for differentiating cases of stroke from stroke mimic was 0.79 (95% confidence interval, 0.69–0.88).ConclusionPatients with ischemic stroke exhibit increases in whole blood viscosity, suggesting that blood viscosity measurements can aid in differentiating ischemic stroke from other diseases.https://www.frontiersin.org/articles/10.3389/fneur.2023.1320773/fullbloodviscosityparallel plateischemic strokeacute stroke |
| spellingShingle | Jihoon Kang Ju Seok Oh Beom Joon Kim Jun Yup Kim Do Yeon Kim So-Yeon Yun Moon-Ku Han Hee-Joon Bae Inwon Park Jae Hyuk Lee You Hwan Jo Kyung Hyun Ahn High blood viscosity in acute ischemic stroke Frontiers in Neurology blood viscosity parallel plate ischemic stroke acute stroke |
| title | High blood viscosity in acute ischemic stroke |
| title_full | High blood viscosity in acute ischemic stroke |
| title_fullStr | High blood viscosity in acute ischemic stroke |
| title_full_unstemmed | High blood viscosity in acute ischemic stroke |
| title_short | High blood viscosity in acute ischemic stroke |
| title_sort | high blood viscosity in acute ischemic stroke |
| topic | blood viscosity parallel plate ischemic stroke acute stroke |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1320773/full |
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