How Does Entacapon Affect Homocysteine Levels?
Objective: To determine homocysteine, vitamin B12, and folate levels in patients with Parkinson’s disease and to investigate the effect of entacapone use on homocysteine levels. Materials and Methods: The records of patients who were followed up in our outpatient clinic between 2009 and 2010 were r...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-06-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-60094&look4= |
| _version_ | 1797905916546252800 |
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| author | Gönül Akdağ Feriha Özer Mithat Bedir Özlem Çokar Belgin Petek Balcı Gülsün Gül |
| author_facet | Gönül Akdağ Feriha Özer Mithat Bedir Özlem Çokar Belgin Petek Balcı Gülsün Gül |
| author_sort | Gönül Akdağ |
| collection | DOAJ |
| description | Objective: To determine homocysteine, vitamin B12, and folate levels in patients with Parkinson’s disease and to investigate the effect of entacapone use on homocysteine levels.
Materials and Methods: The records of patients who were followed up in our outpatient clinic between 2009 and 2010 were reviewed retrospectively. The demographic, clinical characteristics, and laboratory findings of the patients were recorded. The control group consisted of healthy subjects with similar demographic characteristics. The patients were divided into two groups according to the treatment they received.
Results: The control group consisted of 22 healthy subjects (group 1), group 2 comprised 22 patients [entacapone (+)], and group 3 constitued 50 patients [entacapone (-)]. The homocysteine levels of the control group were significantly lower than the entacapone (-) and entacapone (+) groups. The vitamin B12 level of the control group was significantly higher than in the entacapone (-) group. The folate levels of the control group were significantly higher than those of the entacapone (-) group. There was no significant difference between the entacapone (-) and entacapone (+) groups in terms of homocysteine, vitamin B12, and folate levels.
Conclusion: Levodopa treatment affects homocysteine levels in patients with Parkinson’s disease. The effect of levodopa + entacapone on plasma homocysteine levels should be evaluated together with basal vitamin B12 and folate levels and genetic features. |
| first_indexed | 2024-04-10T10:12:49Z |
| format | Article |
| id | doaj.art-c1bd3282697a421f9604f78020037791 |
| institution | Directory Open Access Journal |
| issn | 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T10:12:49Z |
| publishDate | 2021-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-c1bd3282697a421f9604f780200377912023-02-15T16:22:03ZengGalenos YayineviTürk Nöroloji Dergisi1309-25452021-06-0127214515010.4274/tnd.2021.60094How Does Entacapon Affect Homocysteine Levels?Gönül Akdağ0https://orcid.org/0000-0002-0486-6026Feriha Özer1https://orcid.org/0000-0002-0012-2708Mithat Bedir2https://orcid.org/0000-0002-7658-1898Özlem Çokar3https://orcid.org/0000-0003-0231-1091Belgin Petek Balcı4https://orcid.org/0000-0001-5190-7380Gülsün Gül5https://orcid.org/0000-0002-1850-2485Kutahya Health Sciences University Faculty of Medicine, Department of Neurology, Kutahya, TurkeyKoc University Faculty of Medicine, Department of Neurology, Istanbul, TurkeyMardin State Hospital, Clinic of Neurology, Mardin, TurkeyUniversity of Health Sciences Turkey, Istanbul Haseki Training and Research Hospital, Clinic of Neurology, Istanbul, TurkeyUniversity of Health Sciences Turkey, Istanbul Haseki Training and Research Hospital, Clinic of Neurology, Istanbul, TurkeyDortyol State Hospital, Clinic of Neurology, Hatay, TurkeyObjective: To determine homocysteine, vitamin B12, and folate levels in patients with Parkinson’s disease and to investigate the effect of entacapone use on homocysteine levels. Materials and Methods: The records of patients who were followed up in our outpatient clinic between 2009 and 2010 were reviewed retrospectively. The demographic, clinical characteristics, and laboratory findings of the patients were recorded. The control group consisted of healthy subjects with similar demographic characteristics. The patients were divided into two groups according to the treatment they received. Results: The control group consisted of 22 healthy subjects (group 1), group 2 comprised 22 patients [entacapone (+)], and group 3 constitued 50 patients [entacapone (-)]. The homocysteine levels of the control group were significantly lower than the entacapone (-) and entacapone (+) groups. The vitamin B12 level of the control group was significantly higher than in the entacapone (-) group. The folate levels of the control group were significantly higher than those of the entacapone (-) group. There was no significant difference between the entacapone (-) and entacapone (+) groups in terms of homocysteine, vitamin B12, and folate levels. Conclusion: Levodopa treatment affects homocysteine levels in patients with Parkinson’s disease. The effect of levodopa + entacapone on plasma homocysteine levels should be evaluated together with basal vitamin B12 and folate levels and genetic features.https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-60094&look4=idiopathic parkinson’s diseaseentacaponehomocysteine |
| spellingShingle | Gönül Akdağ Feriha Özer Mithat Bedir Özlem Çokar Belgin Petek Balcı Gülsün Gül How Does Entacapon Affect Homocysteine Levels? Türk Nöroloji Dergisi idiopathic parkinson’s disease entacapone homocysteine |
| title | How Does Entacapon Affect Homocysteine Levels? |
| title_full | How Does Entacapon Affect Homocysteine Levels? |
| title_fullStr | How Does Entacapon Affect Homocysteine Levels? |
| title_full_unstemmed | How Does Entacapon Affect Homocysteine Levels? |
| title_short | How Does Entacapon Affect Homocysteine Levels? |
| title_sort | how does entacapon affect homocysteine levels |
| topic | idiopathic parkinson’s disease entacapone homocysteine |
| url | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-60094&look4= |
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