Celecoxib-Induced Modulation of Colon Cancer CD133 Expression Occurs through AKT Inhibition and Is Monitored by 89Zr Immuno-PET

Celecoxib-Induced Modulation of Colon Cancer CD133 Expression Occurs through AKT Inhibition and Is Monitored by 89Zr Immuno-PET

We developed an immuno-PET technique that monitors modulation of tumor CD133 expression, which is required for the success of CD133-targeted therapies. Methods. Anti-CD133 antibodies were subjected to sulfhydryl moiety-specific 89Zr conjugation. 89Zr-CD133 IgG was evaluated for specific activity and...

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Bibliographic Details
Main Authors:	Kyung-Ho Jung, Jin Hee Lee, Mina Kim, Eun Ji Lee, Young Seok Cho, Kyung-Han Lee
Format:	Article
Language:	English
Published:	SAGE Publications 2022-01-01
Series:	Molecular Imaging
Online Access:	http://dx.doi.org/10.1155/2022/4906934

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