PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study
The treatment of large bone defects represents a major clinical challenge. 3D printed scaffolds appear as a promising strategy to support bone defect regeneration. The 3D design of such scaffolds impacts the healing path and thus defect regeneration potential. Among others, scaffold architecture has...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.995266/full |
| _version_ | 1798001492152549376 |
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| author | Mahdi Jaber Mahdi Jaber Patrina S. P. Poh Georg N. Duda Georg N. Duda Sara Checa |
| author_facet | Mahdi Jaber Mahdi Jaber Patrina S. P. Poh Georg N. Duda Georg N. Duda Sara Checa |
| author_sort | Mahdi Jaber |
| collection | DOAJ |
| description | The treatment of large bone defects represents a major clinical challenge. 3D printed scaffolds appear as a promising strategy to support bone defect regeneration. The 3D design of such scaffolds impacts the healing path and thus defect regeneration potential. Among others, scaffold architecture has been shown to influence the healing outcome. Gyroid architecture, characterized by a zero mean surface curvature, has been discussed as a promising scaffold design for bone regeneration. However, whether gyroid scaffolds are favourable for bone regeneration in large bone defects over traditional strut-like architecture scaffolds remains unknown. Therefore, the aim of this study was to investigate whether gyroid scaffolds present advantages over more traditional strut-like scaffolds in terms of their bone regeneration potential. Validated bone defect regeneration principles were applied in an in silico modeling approach that allows to predict bone formation in defect regeneration. Towards this aim, the mechano-biological bone regeneration principles were adapted to allow simulating bone regeneration within both gyroid and strut-like scaffolds. We found that the large surface curvatures of the gyroid scaffold led to a slower tissue formation dynamic and conclusively reduced bone regeneration. The initial claim, that an overall reduced zero mean surface curvature would enhance bone formation, could not be confirmed. The here presented approach illustrates the potential of in silico tools to evaluate in pre-clinical studies scaffold designs and eventually lead to optimized architectures of 3D printed implants for bone regeneration. |
| first_indexed | 2024-04-11T11:37:06Z |
| format | Article |
| id | doaj.art-c1c05c9c29554767911cb24a0d27737b |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T11:37:06Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-c1c05c9c29554767911cb24a0d27737b2022-12-22T04:25:56ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.995266995266PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico studyMahdi Jaber0Mahdi Jaber1Patrina S. P. Poh2Georg N. Duda3Georg N. Duda4Sara Checa5Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, GermanyBerlin-Brandenburg School for Regenerative Therapies, Berlin, GermanyBerlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, GermanyBerlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, GermanyBIH Center for Regenerative Therapies, Berlin, GermanyBerlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, GermanyThe treatment of large bone defects represents a major clinical challenge. 3D printed scaffolds appear as a promising strategy to support bone defect regeneration. The 3D design of such scaffolds impacts the healing path and thus defect regeneration potential. Among others, scaffold architecture has been shown to influence the healing outcome. Gyroid architecture, characterized by a zero mean surface curvature, has been discussed as a promising scaffold design for bone regeneration. However, whether gyroid scaffolds are favourable for bone regeneration in large bone defects over traditional strut-like architecture scaffolds remains unknown. Therefore, the aim of this study was to investigate whether gyroid scaffolds present advantages over more traditional strut-like scaffolds in terms of their bone regeneration potential. Validated bone defect regeneration principles were applied in an in silico modeling approach that allows to predict bone formation in defect regeneration. Towards this aim, the mechano-biological bone regeneration principles were adapted to allow simulating bone regeneration within both gyroid and strut-like scaffolds. We found that the large surface curvatures of the gyroid scaffold led to a slower tissue formation dynamic and conclusively reduced bone regeneration. The initial claim, that an overall reduced zero mean surface curvature would enhance bone formation, could not be confirmed. The here presented approach illustrates the potential of in silico tools to evaluate in pre-clinical studies scaffold designs and eventually lead to optimized architectures of 3D printed implants for bone regeneration.https://www.frontiersin.org/articles/10.3389/fbioe.2022.995266/fullmechano-biologybone defect healing3D-printed scaffold designbone tissue engineeringgyroidTPMS |
| spellingShingle | Mahdi Jaber Mahdi Jaber Patrina S. P. Poh Georg N. Duda Georg N. Duda Sara Checa PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study Frontiers in Bioengineering and Biotechnology mechano-biology bone defect healing 3D-printed scaffold design bone tissue engineering gyroid TPMS |
| title | PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study |
| title_full | PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study |
| title_fullStr | PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study |
| title_full_unstemmed | PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study |
| title_short | PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study |
| title_sort | pcl strut like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect an in silico study |
| topic | mechano-biology bone defect healing 3D-printed scaffold design bone tissue engineering gyroid TPMS |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.995266/full |
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