Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review
Aging and the emergence of age-associated illnesses are one of the major challenges of our present society. Alzheimer’s disease (AD) is closely associated with aging and is defined by increasing memory loss and severe dementia. Currently, there are no therapy options available that halt AD progressi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/24/6018 |
| _version_ | 1827699720030519296 |
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| author | Reinhard Gruendler Berit Hippe Vesna Sendula Jengic Borut Peterlin Alexander G. Haslberger |
| author_facet | Reinhard Gruendler Berit Hippe Vesna Sendula Jengic Borut Peterlin Alexander G. Haslberger |
| author_sort | Reinhard Gruendler |
| collection | DOAJ |
| description | Aging and the emergence of age-associated illnesses are one of the major challenges of our present society. Alzheimer’s disease (AD) is closely associated with aging and is defined by increasing memory loss and severe dementia. Currently, there are no therapy options available that halt AD progression. This work investigates three hallmarks of the disease (autophagy, neuroinflammation, and senescence) and systematically analyzes if there is a beneficial effect from three substances derived from food sources, the so called “nutraceuticals” epigallocatechin gallate, fisetin, and spermidine, on these hallmarks. The results imply a positive outlook for the reviewed substances to qualify as a novel treatment option for AD. A combination of nutraceutical substances and other preventive measures could have significant clinical impact in a multi-layered therapy approach to counter AD. |
| first_indexed | 2024-03-10T13:56:32Z |
| format | Article |
| id | doaj.art-c1c0e55dbfc7415aa9b73adcde7a010f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:56:32Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c1c0e55dbfc7415aa9b73adcde7a010f2023-11-21T01:35:41ZengMDPI AGMolecules1420-30492020-12-012524601810.3390/molecules25246018Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic ReviewReinhard Gruendler0Berit Hippe1Vesna Sendula Jengic2Borut Peterlin3Alexander G. Haslberger4Department of Pharmacology and Toxicology, University of Vienna, A-1090 Vienna, AustriaDepartment of Nutritional Sciences, University of Vienna, A-1090 Vienna, AustriaHealthBioCare, Nußdorfer Street 67, A-1090 Vienna, AustriaRab Psychiatric Hospital, 51280 Kampor, CroatiaDepartment of Nutritional Sciences, University of Vienna, A-1090 Vienna, AustriaAging and the emergence of age-associated illnesses are one of the major challenges of our present society. Alzheimer’s disease (AD) is closely associated with aging and is defined by increasing memory loss and severe dementia. Currently, there are no therapy options available that halt AD progression. This work investigates three hallmarks of the disease (autophagy, neuroinflammation, and senescence) and systematically analyzes if there is a beneficial effect from three substances derived from food sources, the so called “nutraceuticals” epigallocatechin gallate, fisetin, and spermidine, on these hallmarks. The results imply a positive outlook for the reviewed substances to qualify as a novel treatment option for AD. A combination of nutraceutical substances and other preventive measures could have significant clinical impact in a multi-layered therapy approach to counter AD.https://www.mdpi.com/1420-3049/25/24/6018neuroinflammationcognitive declineepigeneticautophagyEGCGfisetin |
| spellingShingle | Reinhard Gruendler Berit Hippe Vesna Sendula Jengic Borut Peterlin Alexander G. Haslberger Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review Molecules neuroinflammation cognitive decline epigenetic autophagy EGCG fisetin |
| title | Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review |
| title_full | Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review |
| title_fullStr | Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review |
| title_full_unstemmed | Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review |
| title_short | Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review |
| title_sort | nutraceutical approaches of autophagy and neuroinflammation in alzheimer s disease a systematic review |
| topic | neuroinflammation cognitive decline epigenetic autophagy EGCG fisetin |
| url | https://www.mdpi.com/1420-3049/25/24/6018 |
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