Microglial ferroptotic stress causes non-cell autonomous neuronal death

Microglial ferroptotic stress causes non-cell autonomous neuronal death

Abstract Background Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing neuronal death in degenerative diseases of the centr...

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Main Authors: Jeffrey R. Liddell, James B. W. Hilton, Kai Kysenius, Jessica L. Billings, Sara Nikseresht, Lachlan E. McInnes, Dominic J. Hare, Bence Paul, Stephen W. Mercer, Abdel A. Belaidi, Scott Ayton, Blaine R. Roberts, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Peter J. Crouch
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Molecular Neurodegeneration
Subjects:
Microglia
Ferroptosis
Amyotrophic lateral sclerosis (ALS)
Neurotoxic astrocytes
Glial activation
Therapy
Online Access:https://doi.org/10.1186/s13024-023-00691-8

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