Seroprevalence of leptospirosis among blood donors in an endemic area
Abstract Thailand is known to be endemic for leptospirosis. This bacterium may pose a potential risk to transfusion safety. This study was a cross-sectional study examining the seroprevalence of leptospirosis among Thai blood donors. A total of 1053 serum specimens collected from blood donors residi...
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| Format: | Article |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-39461-3 |
| _version_ | 1797752793254068224 |
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| author | Umaporn Limothai Sasipha Tachaboon Janejira Dinhuzen Jasleen Singh Sirawit Jirawannaporn Akarathep Leewongworasingh Matsaya Thongpin Suppalak Brameld Phandee Watanaboonyongcharoen Visith Sitprija Terapong Tantawichien Usa Thisyakorn Nattachai Srisawat |
| author_facet | Umaporn Limothai Sasipha Tachaboon Janejira Dinhuzen Jasleen Singh Sirawit Jirawannaporn Akarathep Leewongworasingh Matsaya Thongpin Suppalak Brameld Phandee Watanaboonyongcharoen Visith Sitprija Terapong Tantawichien Usa Thisyakorn Nattachai Srisawat |
| author_sort | Umaporn Limothai |
| collection | DOAJ |
| description | Abstract Thailand is known to be endemic for leptospirosis. This bacterium may pose a potential risk to transfusion safety. This study was a cross-sectional study examining the seroprevalence of leptospirosis among Thai blood donors. A total of 1053 serum specimens collected from blood donors residing in 5 regions of Thailand during March to September 2020 were included in this study. All samples were tested for the presence of antibodies to 22 leptospiral serovars using the microscopic agglutination test (MAT) and anti-Leptospira IgG antibodies using commercially available enzyme immunoassay. We found no evidence of recent exposure to Leptospira spp. in sera of healthy Thai blood donors by MAT, including those in higher-risk areas. However, in this same group, we did find small numbers of past exposure (1.7%) to Leptospira spp. by IgG ELISA. According to the findings of this study, there is currently no evidence for implementing new blood banking procedures to identify possible carriers in Thailand, however these should be continually monitored and revised according to the infectious disease burden in each country. It should be noted that there was a difference in the occupation rate between the general population reported in Thailand and blood donors in this study; it may not reflect the actual situation in the country. |
| first_indexed | 2024-03-12T17:09:35Z |
| format | Article |
| id | doaj.art-c1c52bb301964651b94e352669df4ff1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T17:09:35Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-c1c52bb301964651b94e352669df4ff12023-08-06T11:11:28ZengNature PortfolioScientific Reports2045-23222023-07-011311910.1038/s41598-023-39461-3Seroprevalence of leptospirosis among blood donors in an endemic areaUmaporn Limothai0Sasipha Tachaboon1Janejira Dinhuzen2Jasleen Singh3Sirawit Jirawannaporn4Akarathep Leewongworasingh5Matsaya Thongpin6Suppalak Brameld7Phandee Watanaboonyongcharoen8Visith Sitprija9Terapong Tantawichien10Usa Thisyakorn11Nattachai Srisawat12Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial HospitalExcellence Center for Critical Care Nephrology, King Chulalongkorn Memorial HospitalExcellence Center for Critical Care Nephrology, King Chulalongkorn Memorial HospitalTropical Medicine Cluster, Chulalongkorn UniversityExcellence Center for Critical Care Nephrology, King Chulalongkorn Memorial HospitalExcellence Center for Critical Care Nephrology, King Chulalongkorn Memorial HospitalNational Institute of Health of ThailandNational Institute of Health of ThailandDepartment of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University and Transfusion Medicine Unit, King Chulalongkorn Memorial HospitalThai Red Cross, Queen Saovabha Memorial InstituteTropical Medicine Cluster, Chulalongkorn UniversityTropical Medicine Cluster, Chulalongkorn UniversityExcellence Center for Critical Care Nephrology, King Chulalongkorn Memorial HospitalAbstract Thailand is known to be endemic for leptospirosis. This bacterium may pose a potential risk to transfusion safety. This study was a cross-sectional study examining the seroprevalence of leptospirosis among Thai blood donors. A total of 1053 serum specimens collected from blood donors residing in 5 regions of Thailand during March to September 2020 were included in this study. All samples were tested for the presence of antibodies to 22 leptospiral serovars using the microscopic agglutination test (MAT) and anti-Leptospira IgG antibodies using commercially available enzyme immunoassay. We found no evidence of recent exposure to Leptospira spp. in sera of healthy Thai blood donors by MAT, including those in higher-risk areas. However, in this same group, we did find small numbers of past exposure (1.7%) to Leptospira spp. by IgG ELISA. According to the findings of this study, there is currently no evidence for implementing new blood banking procedures to identify possible carriers in Thailand, however these should be continually monitored and revised according to the infectious disease burden in each country. It should be noted that there was a difference in the occupation rate between the general population reported in Thailand and blood donors in this study; it may not reflect the actual situation in the country.https://doi.org/10.1038/s41598-023-39461-3 |
| spellingShingle | Umaporn Limothai Sasipha Tachaboon Janejira Dinhuzen Jasleen Singh Sirawit Jirawannaporn Akarathep Leewongworasingh Matsaya Thongpin Suppalak Brameld Phandee Watanaboonyongcharoen Visith Sitprija Terapong Tantawichien Usa Thisyakorn Nattachai Srisawat Seroprevalence of leptospirosis among blood donors in an endemic area Scientific Reports |
| title | Seroprevalence of leptospirosis among blood donors in an endemic area |
| title_full | Seroprevalence of leptospirosis among blood donors in an endemic area |
| title_fullStr | Seroprevalence of leptospirosis among blood donors in an endemic area |
| title_full_unstemmed | Seroprevalence of leptospirosis among blood donors in an endemic area |
| title_short | Seroprevalence of leptospirosis among blood donors in an endemic area |
| title_sort | seroprevalence of leptospirosis among blood donors in an endemic area |
| url | https://doi.org/10.1038/s41598-023-39461-3 |
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