The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target
The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19. However, some SARS-CoV-2 variants of concern (VOCs) have emerged that ev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/4/1000 |
| _version_ | 1797603236341874688 |
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| author | Teresa Santos-Mendoza |
| author_facet | Teresa Santos-Mendoza |
| author_sort | Teresa Santos-Mendoza |
| collection | DOAJ |
| description | The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19. However, some SARS-CoV-2 variants of concern (VOCs) have emerged that evade the protective effect of vaccine-induced antibodies. Therefore, efficient and specific antiviral treatments to control COVID-19 are indispensable. To date, two drugs have been approved for mild COVID-19 treatment; nevertheless, more drugs, preferably broad-spectrum and ready-to-use therapeutic agents for new pandemics, are needed. Here, I discuss the PDZ-dependent protein-protein interactions of the viral E protein with host proteins as attractive alternatives for the development of antivirals against coronavirus. |
| first_indexed | 2024-03-11T04:26:29Z |
| format | Article |
| id | doaj.art-c1c9fb472da74d1e9cd3076fc211b817 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:29Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c1c9fb472da74d1e9cd3076fc211b8172023-11-17T21:46:47ZengMDPI AGViruses1999-49152023-04-01154100010.3390/v15041000The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological TargetTeresa Santos-Mendoza0Laboratory of Transcriptomics and Molecular Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoThe COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19. However, some SARS-CoV-2 variants of concern (VOCs) have emerged that evade the protective effect of vaccine-induced antibodies. Therefore, efficient and specific antiviral treatments to control COVID-19 are indispensable. To date, two drugs have been approved for mild COVID-19 treatment; nevertheless, more drugs, preferably broad-spectrum and ready-to-use therapeutic agents for new pandemics, are needed. Here, I discuss the PDZ-dependent protein-protein interactions of the viral E protein with host proteins as attractive alternatives for the development of antivirals against coronavirus.https://www.mdpi.com/1999-4915/15/4/1000coronavirus E proteinPDZ-dependent interactionsantivirals |
| spellingShingle | Teresa Santos-Mendoza The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target Viruses coronavirus E protein PDZ-dependent interactions antivirals |
| title | The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target |
| title_full | The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target |
| title_fullStr | The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target |
| title_full_unstemmed | The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target |
| title_short | The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target |
| title_sort | envelope e protein of sars cov 2 as a pharmacological target |
| topic | coronavirus E protein PDZ-dependent interactions antivirals |
| url | https://www.mdpi.com/1999-4915/15/4/1000 |
| work_keys_str_mv | AT teresasantosmendoza theenvelopeeproteinofsarscov2asapharmacologicaltarget AT teresasantosmendoza envelopeeproteinofsarscov2asapharmacologicaltarget |