Mechanisms of endothelial dysfunction in obesity-associated hypertension
Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of g...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2012-05-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500003 |
| _version_ | 1818020456922349568 |
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| author | N.S. Lobato F.P. Filgueira E.H. Akamine R.C. Tostes M.H.C. Carvalho Z.B. Fortes |
| author_facet | N.S. Lobato F.P. Filgueira E.H. Akamine R.C. Tostes M.H.C. Carvalho Z.B. Fortes |
| author_sort | N.S. Lobato |
| collection | DOAJ |
| description | Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a primary risk factor in the development of hypertension. Additional mechanisms also related to endothelial dysfunction have been proposed to mediate the development of hypertension in obese individuals. These include: increase in both peripheral vasoconstriction and renal tubular sodium reabsorption, increased sympathetic activity and overactivation of both the renin-angiotensin system and the endocannabinoid system and insulin resistance. The discovery of new mechanisms regulating metabolic and vascular function and a better understanding of how vascular function can be influenced by these systems would facilitate the development of new therapies for treatment of obesity-associated hypertension. |
| first_indexed | 2024-04-14T08:05:35Z |
| format | Article |
| id | doaj.art-c1cb3bdd05cb4f57a093c7ffb2cfd80b |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-14T08:05:35Z |
| publishDate | 2012-05-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-c1cb3bdd05cb4f57a093c7ffb2cfd80b2022-12-22T02:04:46ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2012-05-01455392400Mechanisms of endothelial dysfunction in obesity-associated hypertensionN.S. LobatoF.P. FilgueiraE.H. AkamineR.C. TostesM.H.C. CarvalhoZ.B. FortesObesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a primary risk factor in the development of hypertension. Additional mechanisms also related to endothelial dysfunction have been proposed to mediate the development of hypertension in obese individuals. These include: increase in both peripheral vasoconstriction and renal tubular sodium reabsorption, increased sympathetic activity and overactivation of both the renin-angiotensin system and the endocannabinoid system and insulin resistance. The discovery of new mechanisms regulating metabolic and vascular function and a better understanding of how vascular function can be influenced by these systems would facilitate the development of new therapies for treatment of obesity-associated hypertension.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500003HypertensionObesityEndothelial dysfunctionOxidative stressRenin-angiotensin systemNitric oxide |
| spellingShingle | N.S. Lobato F.P. Filgueira E.H. Akamine R.C. Tostes M.H.C. Carvalho Z.B. Fortes Mechanisms of endothelial dysfunction in obesity-associated hypertension Brazilian Journal of Medical and Biological Research Hypertension Obesity Endothelial dysfunction Oxidative stress Renin-angiotensin system Nitric oxide |
| title | Mechanisms of endothelial dysfunction in obesity-associated hypertension |
| title_full | Mechanisms of endothelial dysfunction in obesity-associated hypertension |
| title_fullStr | Mechanisms of endothelial dysfunction in obesity-associated hypertension |
| title_full_unstemmed | Mechanisms of endothelial dysfunction in obesity-associated hypertension |
| title_short | Mechanisms of endothelial dysfunction in obesity-associated hypertension |
| title_sort | mechanisms of endothelial dysfunction in obesity associated hypertension |
| topic | Hypertension Obesity Endothelial dysfunction Oxidative stress Renin-angiotensin system Nitric oxide |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500003 |
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