Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates
Detection and characterization of cells using aptamers and aptamer-conjugated nanoprobes has evolved a great deal over the past few decades. This evolution has been driven by the easy selection of aptamers via in vitro cell-SELEX, permitting sensitive discrimination between target and normal cells,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-09-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/14/10/18302 |
| _version_ | 1798043236546117632 |
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| author | Vinayakumar Gedi Young-Pil Kim |
| author_facet | Vinayakumar Gedi Young-Pil Kim |
| author_sort | Vinayakumar Gedi |
| collection | DOAJ |
| description | Detection and characterization of cells using aptamers and aptamer-conjugated nanoprobes has evolved a great deal over the past few decades. This evolution has been driven by the easy selection of aptamers via in vitro cell-SELEX, permitting sensitive discrimination between target and normal cells, which includes pathogenic prokaryotic and cancerous eukaryotic cells. Additionally, when the aptamer-based strategies are used in conjunction with nanomaterials, there is the potential for cell targeting and therapeutic effects with improved specificity and sensitivity. Here we review recent advances in aptamer-based nano-conjugates and their applications for detecting cancer cells and pathogenic bacteria. The multidisciplinary research utilized in this field will play an increasingly significant role in clinical medicine and drug discovery. |
| first_indexed | 2024-04-11T22:46:33Z |
| format | Article |
| id | doaj.art-c1cb9f95a6974974862049396f63f8a4 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T22:46:33Z |
| publishDate | 2014-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-c1cb9f95a6974974862049396f63f8a42022-12-22T03:58:44ZengMDPI AGSensors1424-82202014-09-011410183021832710.3390/s141018302s141018302Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-ConjugatesVinayakumar Gedi0Young-Pil Kim1Department of Life Science, Hanyang University, Seoul 133-791, KoreaDepartment of Life Science, Hanyang University, Seoul 133-791, KoreaDetection and characterization of cells using aptamers and aptamer-conjugated nanoprobes has evolved a great deal over the past few decades. This evolution has been driven by the easy selection of aptamers via in vitro cell-SELEX, permitting sensitive discrimination between target and normal cells, which includes pathogenic prokaryotic and cancerous eukaryotic cells. Additionally, when the aptamer-based strategies are used in conjunction with nanomaterials, there is the potential for cell targeting and therapeutic effects with improved specificity and sensitivity. Here we review recent advances in aptamer-based nano-conjugates and their applications for detecting cancer cells and pathogenic bacteria. The multidisciplinary research utilized in this field will play an increasingly significant role in clinical medicine and drug discovery.http://www.mdpi.com/1424-8220/14/10/18302aptamercell-SELEXbacteriacancer cellnanoparticlenanomaterial |
| spellingShingle | Vinayakumar Gedi Young-Pil Kim Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates Sensors aptamer cell-SELEX bacteria cancer cell nanoparticle nanomaterial |
| title | Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates |
| title_full | Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates |
| title_fullStr | Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates |
| title_full_unstemmed | Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates |
| title_short | Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates |
| title_sort | detection and characterization of cancer cells and pathogenic bacteria using aptamer based nano conjugates |
| topic | aptamer cell-SELEX bacteria cancer cell nanoparticle nanomaterial |
| url | http://www.mdpi.com/1424-8220/14/10/18302 |
| work_keys_str_mv | AT vinayakumargedi detectionandcharacterizationofcancercellsandpathogenicbacteriausingaptamerbasednanoconjugates AT youngpilkim detectionandcharacterizationofcancercellsandpathogenicbacteriausingaptamerbasednanoconjugates |