Factors associated with higher falling risk in elderly diabetic patients with lacunar stroke
Abstract Purpose The aim of this study is to explore the factors associated with the fall risk in type 2 diabetes (T2D) patients with a lacunar stroke. Materials and methods We compiled data of 146 T2D patients (mean age 68 years), including the Morse fall scale data (MFS), nutrition score, self-car...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01122-3 |
| _version_ | 1828183315224461312 |
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| author | Jianlan Jin Song Wen Yanyan Li Mingyue Zhou Qingqing Duan Ligang Zhou |
| author_facet | Jianlan Jin Song Wen Yanyan Li Mingyue Zhou Qingqing Duan Ligang Zhou |
| author_sort | Jianlan Jin |
| collection | DOAJ |
| description | Abstract Purpose The aim of this study is to explore the factors associated with the fall risk in type 2 diabetes (T2D) patients with a lacunar stroke. Materials and methods We compiled data of 146 T2D patients (mean age 68 years), including the Morse fall scale data (MFS), nutrition score, self-care scale, laboratory data, and data from continuous glucose monitoring system (CGMS) from 2019 to 2021 in Shanghai Pudong Hospital. Thereby, we evaluated the associations between MFS and other clinical parameters. Results The analyses showed that there were significantly increased size and numbers of lacunar infarction (p < 0.05). Furthermore, the greater risk group had an older mean age (p < 0.05), and significant decreased estimated glomerular filtration rate (eGFR), total triglyceride (TG), while increased microalbuminuria, magnesium, lipoprotein A (LP(a)), anti-thyroid peroxidase antibody (TPOAb) (p < 0.05). However, the time in range (TIR) was very comparable (p > 0.05). The correlational study revealed the higher score of MFS was associated with the age (r = 0.41), number of lacunar infarction (r = 0.18), nutrition score (r = 0.20), self-care score (r = − 0.43), serum creatine level (r = 0.19), eGFR (r = − 0.26) (p < 0.05). The total numbers of lacunar infarction were associated with age (r = 0.36), eGFR (r = − 0.40), homocysteine level (r = 0.33) (p < 0.05). Conclusions Age, nutrition, self-care ability, and renal function are all critical factors associated with the risk of fall in T2D with lacunar infarction. The age, eGFR, and homocysteine are closely associated with lacunar infarction, suggesting that in T2D, evaluation of kidney dysfunction, homocysteine level in the elderly can predict lacunar infarcts and falls. |
| first_indexed | 2024-04-12T06:31:47Z |
| format | Article |
| id | doaj.art-c1cc08034b864eff9ce814cdabafb8fd |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-12T06:31:47Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-c1cc08034b864eff9ce814cdabafb8fd2022-12-22T03:44:00ZengBMCBMC Endocrine Disorders1472-68232022-08-012211810.1186/s12902-022-01122-3Factors associated with higher falling risk in elderly diabetic patients with lacunar strokeJianlan Jin0Song Wen1Yanyan Li2Mingyue Zhou3Qingqing Duan4Ligang Zhou5Department of Endocrinology, Shanghai Pudong Hospital, Fudan UniversityDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan UniversityDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan UniversityHelen Driller Family Comprehensive Cancer Center, University of CaliforniaDepartment of Radiology, Shanghai Pudong Hospital, Fudan UniversityDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan UniversityAbstract Purpose The aim of this study is to explore the factors associated with the fall risk in type 2 diabetes (T2D) patients with a lacunar stroke. Materials and methods We compiled data of 146 T2D patients (mean age 68 years), including the Morse fall scale data (MFS), nutrition score, self-care scale, laboratory data, and data from continuous glucose monitoring system (CGMS) from 2019 to 2021 in Shanghai Pudong Hospital. Thereby, we evaluated the associations between MFS and other clinical parameters. Results The analyses showed that there were significantly increased size and numbers of lacunar infarction (p < 0.05). Furthermore, the greater risk group had an older mean age (p < 0.05), and significant decreased estimated glomerular filtration rate (eGFR), total triglyceride (TG), while increased microalbuminuria, magnesium, lipoprotein A (LP(a)), anti-thyroid peroxidase antibody (TPOAb) (p < 0.05). However, the time in range (TIR) was very comparable (p > 0.05). The correlational study revealed the higher score of MFS was associated with the age (r = 0.41), number of lacunar infarction (r = 0.18), nutrition score (r = 0.20), self-care score (r = − 0.43), serum creatine level (r = 0.19), eGFR (r = − 0.26) (p < 0.05). The total numbers of lacunar infarction were associated with age (r = 0.36), eGFR (r = − 0.40), homocysteine level (r = 0.33) (p < 0.05). Conclusions Age, nutrition, self-care ability, and renal function are all critical factors associated with the risk of fall in T2D with lacunar infarction. The age, eGFR, and homocysteine are closely associated with lacunar infarction, suggesting that in T2D, evaluation of kidney dysfunction, homocysteine level in the elderly can predict lacunar infarcts and falls.https://doi.org/10.1186/s12902-022-01122-3Type 2 diabetesFall riskLacunar infarctionAgeMicrovascular diseases |
| spellingShingle | Jianlan Jin Song Wen Yanyan Li Mingyue Zhou Qingqing Duan Ligang Zhou Factors associated with higher falling risk in elderly diabetic patients with lacunar stroke BMC Endocrine Disorders Type 2 diabetes Fall risk Lacunar infarction Age Microvascular diseases |
| title | Factors associated with higher falling risk in elderly diabetic patients with lacunar stroke |
| title_full | Factors associated with higher falling risk in elderly diabetic patients with lacunar stroke |
| title_fullStr | Factors associated with higher falling risk in elderly diabetic patients with lacunar stroke |
| title_full_unstemmed | Factors associated with higher falling risk in elderly diabetic patients with lacunar stroke |
| title_short | Factors associated with higher falling risk in elderly diabetic patients with lacunar stroke |
| title_sort | factors associated with higher falling risk in elderly diabetic patients with lacunar stroke |
| topic | Type 2 diabetes Fall risk Lacunar infarction Age Microvascular diseases |
| url | https://doi.org/10.1186/s12902-022-01122-3 |
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