Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group

Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group

Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic properties have been attributed to the presence of the nitro group. However, we synthesised nitroimidazoles with activity against the trypomastigotes of Trypanosoma cruzi, but that were not genotoxic. Herein,...

Full description

Bibliographic Details
Main Authors: Núbia Boechat, Alcione S Carvalho, Kelly Salomão, Solange L de Castro, Carlos F Araujo-Lima, Francisco VC Mello, Israel Felzenszwalb, Claudia AF Aiub, Taline Ramos Conde, Helena PS Zamith, Rolf Skupin, Günter Haufe
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2015-06-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
nitroimidazoles
genotoxicity
mutagenicity
trypanocidal activity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000400492&lng=en&tlng=en

Similar Items

Similar Items