The influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patients
Objective: This study aimed to investigate the influence of periodontal status, clinical data, and serum markers on salivary leptin levels in patients with systemic lupus erythematosus (SLE). Methods: A case–control study was conducted with 38 patients with SLE and 29 healthy controls. Periodontal d...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905222001377 |
| _version_ | 1811201871168143360 |
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| author | Leslie A. da Silva Consuelo P.C. Marques Izabel C.V. de Oliveira Mayra M. Franco Vandilson P. Rodrigues Bruno B. Benatti |
| author_facet | Leslie A. da Silva Consuelo P.C. Marques Izabel C.V. de Oliveira Mayra M. Franco Vandilson P. Rodrigues Bruno B. Benatti |
| author_sort | Leslie A. da Silva |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the influence of periodontal status, clinical data, and serum markers on salivary leptin levels in patients with systemic lupus erythematosus (SLE). Methods: A case–control study was conducted with 38 patients with SLE and 29 healthy controls. Periodontal data included periodontal probing depth (PPD), clinical attachment level (CAL), and gingival bleeding on probing (BOP). Stimulated saliva samples were collected to analyze salivary leptin levels. Clinical and serum data were collected from the SLE group. Statistical analysis included the t-test, Mann–Whitney test, Spearman correlation coefficient, and a structural equation model. Results: The SLE group had a lower salivary leptin level than the control group (P = 0.002). The model revealed that SLE had an inverse and independent effect on salivary leptin (standardized estimate = − 0.289, P = 0.023). Moreover, salivary leptin level negatively correlated with the serum levels of triglyceride, creatinine, and leukocytes, positively correlated with the serum total cholesterol, but was not significantly correlated with the periodontal status. Conclusion: These findings suggest that patients with SLE have a lower salivary leptin level. In addition, the level of salivary leptin does not appear to be related to periodontal status in patients with SLE. |
| first_indexed | 2024-04-12T02:29:11Z |
| format | Article |
| id | doaj.art-c1cc951e29a0479f859948f7afd3f812 |
| institution | Directory Open Access Journal |
| issn | 1013-9052 |
| language | English |
| last_indexed | 2024-04-12T02:29:11Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj.art-c1cc951e29a0479f859948f7afd3f8122022-12-22T03:51:51ZengElsevierSaudi Dental Journal1013-90522022-12-01348708714The influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patientsLeslie A. da Silva0Consuelo P.C. Marques1Izabel C.V. de Oliveira2Mayra M. Franco3Vandilson P. Rodrigues4Bruno B. Benatti5Dentistry Graduate Program, Federal University of Maranhão, São Luís, BrazilDentistry Graduate Program, Federal University of Maranhão, São Luís, Brazil; School of Medicine, Federal University of Maranhão, Pinheiro, BrazilDentistry Graduate Program, Federal University of Maranhão, São Luís, BrazilDentistry Graduate Program, Federal University of Maranhão, São Luís, BrazilDentistry Graduate Program, Federal University of Maranhão, São Luís, Brazil; Department of Morphology, Federal University of Maranhão, São Luís, Brazil; Corresponding author at: Universidade Federal do Maranhão, Programa de Pós-Graduação em Odontologia, Avenida dos Portugueses, 1966, Campus Universitário do Bacanga, Zip Code 65085-580, São Luís, MA, Brazil.Dentistry Graduate Program, Federal University of Maranhão, São Luís, BrazilObjective: This study aimed to investigate the influence of periodontal status, clinical data, and serum markers on salivary leptin levels in patients with systemic lupus erythematosus (SLE). Methods: A case–control study was conducted with 38 patients with SLE and 29 healthy controls. Periodontal data included periodontal probing depth (PPD), clinical attachment level (CAL), and gingival bleeding on probing (BOP). Stimulated saliva samples were collected to analyze salivary leptin levels. Clinical and serum data were collected from the SLE group. Statistical analysis included the t-test, Mann–Whitney test, Spearman correlation coefficient, and a structural equation model. Results: The SLE group had a lower salivary leptin level than the control group (P = 0.002). The model revealed that SLE had an inverse and independent effect on salivary leptin (standardized estimate = − 0.289, P = 0.023). Moreover, salivary leptin level negatively correlated with the serum levels of triglyceride, creatinine, and leukocytes, positively correlated with the serum total cholesterol, but was not significantly correlated with the periodontal status. Conclusion: These findings suggest that patients with SLE have a lower salivary leptin level. In addition, the level of salivary leptin does not appear to be related to periodontal status in patients with SLE.http://www.sciencedirect.com/science/article/pii/S1013905222001377Systemic lupus erythematosusLeptinSalivaPeriodontal diseases |
| spellingShingle | Leslie A. da Silva Consuelo P.C. Marques Izabel C.V. de Oliveira Mayra M. Franco Vandilson P. Rodrigues Bruno B. Benatti The influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patients Saudi Dental Journal Systemic lupus erythematosus Leptin Saliva Periodontal diseases |
| title | The influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patients |
| title_full | The influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patients |
| title_fullStr | The influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patients |
| title_full_unstemmed | The influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patients |
| title_short | The influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patients |
| title_sort | influence of periodontal status and serum biomarkers on salivary leptin levels in systemic lupus erythematosus patients |
| topic | Systemic lupus erythematosus Leptin Saliva Periodontal diseases |
| url | http://www.sciencedirect.com/science/article/pii/S1013905222001377 |
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