Carbohydrate-Derived Amphiphilic Macromolecules: A Biophysical Structural Characterization and Analysis of Binding Behaviors to Model Membranes

Carbohydrate-Derived Amphiphilic Macromolecules: A Biophysical Structural Characterization and Analysis of Binding Behaviors to Model Membranes

The design and synthesis of enhanced membrane-intercalating biomaterials for drug delivery or vascular membrane targeting is currently challenged by the lack of screening and prediction tools. The present work demonstrates the generation of a Quantitative Structural Activity Relationship model (QSAR...

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Bibliographic Details
Main Authors:	Adriana A. T. Martin, Michael Tomasini, Vladyslav Kholodovych, Li Gu, Sven Daniel Sommerfeld, Kathryn E. Uhrich, N. Sanjeeva Murthy, William J. Welsh, Prabhas V. Moghe
Format:	Article
Language:	English
Published:	MDPI AG 2015-04-01
Series:	Journal of Functional Biomaterials
Subjects:	amphiphilic macromolecule membrane lipid bilayers quartz crystal microbalance with dissipation (QCM-D) molecular dynamics simulations quantitative structure-activity relationship (QSAR) model
Online Access:	http://www.mdpi.com/2079-4983/6/2/171

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