Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-β Pathway

Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-β Pathway

Akt1 suppression in advanced cancers has been indicated to promote metastasis. Our understanding of how Akt1 orchestrates this is incomplete. Using the NanoString<sup>®</sup>-based miRNA and mRNA profiling of PC3 and DU145 cells, and subsequent data analysis using the DIANA-mirPath, dbEM...

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Bibliographic Details
Main Authors: Abdulrahman Alwhaibi, Varun Parvathagiri, Arti Verma, Sandeep Artham, Mir S. Adil, Payaningal R. Somanath
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
Akt1
miR-199a-5p
let-7a-5p
epithelial-to-mesenchymal transition
prostate cancer
Online Access:https://www.mdpi.com/2072-6694/14/7/1625

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