Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank
Red meat consumption has been found to closely related to cardiometabolic health, with sex disparity. However, the specific metabolic factors corresponding to red meat consumption in men and women have not been examined previously. We analyzed the sex-specific associations of meat consumption, with...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/24/5306 |
| _version_ | 1797455887259926528 |
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| author | Bohan Fan Jie V. Zhao |
| author_facet | Bohan Fan Jie V. Zhao |
| author_sort | Bohan Fan |
| collection | DOAJ |
| description | Red meat consumption has been found to closely related to cardiometabolic health, with sex disparity. However, the specific metabolic factors corresponding to red meat consumption in men and women have not been examined previously. We analyzed the sex-specific associations of meat consumption, with 167 metabolites using multivariable regression, controlling for age, ethnicity, Townsend deprivation index, education, physical activity, smoking, and drinking status among ~79,644 UK Biobank participants. We also compared the sex differences using an established formula. After accounting for multiple testing with false discovery rate < 5% and controlling for confounders, the positive associations of unprocessed red meat consumption with branched-chain amino acids and several lipoproteins, and the inverse association with glycine were stronger in women, while the positive associations with apolipoprotein A1, creatinine, and monounsaturated fatty acids were more obvious in men. For processed meat, the positive associations with branched-chain amino acids, several lipoproteins, tyrosine, lactate, glycoprotein acetyls and inverse associations with glutamine, and glycine were stronger in women than in men. The study suggests that meat consumption has sex-specific associations with several metabolites. This has important implication to provide dietary suggestions for individuals with or at high risk of cardiometabolic disease, with consideration of sex difference. |
| first_indexed | 2024-03-09T16:00:39Z |
| format | Article |
| id | doaj.art-c1d3c776edfd415ab5811eeb17b52331 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:00:39Z |
| publishDate | 2022-12-01 |
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| series | Nutrients |
| spelling | doaj.art-c1d3c776edfd415ab5811eeb17b523312023-11-24T17:09:00ZengMDPI AGNutrients2072-66432022-12-011424530610.3390/nu14245306Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK BiobankBohan Fan0Jie V. Zhao1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaRed meat consumption has been found to closely related to cardiometabolic health, with sex disparity. However, the specific metabolic factors corresponding to red meat consumption in men and women have not been examined previously. We analyzed the sex-specific associations of meat consumption, with 167 metabolites using multivariable regression, controlling for age, ethnicity, Townsend deprivation index, education, physical activity, smoking, and drinking status among ~79,644 UK Biobank participants. We also compared the sex differences using an established formula. After accounting for multiple testing with false discovery rate < 5% and controlling for confounders, the positive associations of unprocessed red meat consumption with branched-chain amino acids and several lipoproteins, and the inverse association with glycine were stronger in women, while the positive associations with apolipoprotein A1, creatinine, and monounsaturated fatty acids were more obvious in men. For processed meat, the positive associations with branched-chain amino acids, several lipoproteins, tyrosine, lactate, glycoprotein acetyls and inverse associations with glutamine, and glycine were stronger in women than in men. The study suggests that meat consumption has sex-specific associations with several metabolites. This has important implication to provide dietary suggestions for individuals with or at high risk of cardiometabolic disease, with consideration of sex difference.https://www.mdpi.com/2072-6643/14/24/5306red meatprocessed meatUK Biobankserum metabolites |
| spellingShingle | Bohan Fan Jie V. Zhao Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank Nutrients red meat processed meat UK Biobank serum metabolites |
| title | Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank |
| title_full | Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank |
| title_fullStr | Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank |
| title_full_unstemmed | Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank |
| title_short | Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank |
| title_sort | sex specific associations of red meat and processed meat consumption with serum metabolites in the uk biobank |
| topic | red meat processed meat UK Biobank serum metabolites |
| url | https://www.mdpi.com/2072-6643/14/24/5306 |
| work_keys_str_mv | AT bohanfan sexspecificassociationsofredmeatandprocessedmeatconsumptionwithserummetabolitesintheukbiobank AT jievzhao sexspecificassociationsofredmeatandprocessedmeatconsumptionwithserummetabolitesintheukbiobank |