Nanomaterials in Skin Regeneration and Rejuvenation
Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/7095 |
| _version_ | 1797528091577286656 |
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| author | Emanuela Bellu Serenella Medici Donatella Coradduzza Sara Cruciani Evzen Amler Margherita Maioli |
| author_facet | Emanuela Bellu Serenella Medici Donatella Coradduzza Sara Cruciani Evzen Amler Margherita Maioli |
| author_sort | Emanuela Bellu |
| collection | DOAJ |
| description | Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration. |
| first_indexed | 2024-03-10T09:53:11Z |
| format | Article |
| id | doaj.art-c1d47d8d199c4ec39277a61057b1f297 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:53:11Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c1d47d8d199c4ec39277a61057b1f2972023-11-22T02:34:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213709510.3390/ijms22137095Nanomaterials in Skin Regeneration and RejuvenationEmanuela Bellu0Serenella Medici1Donatella Coradduzza2Sara Cruciani3Evzen Amler4Margherita Maioli5Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, ItalyDepartment of Chemistry and Pharmacy, University of Sassari, Vienna 2, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, ItalyUniversity Centre for Energy Efficient Buildings of Czech Technical University in Prague, Trinecka 1024, 27343 Bustehrad, Czech RepublicDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, ItalySkin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.https://www.mdpi.com/1422-0067/22/13/7095nanomaterialsstem cellscellular mechanismsskinregenerative medicine |
| spellingShingle | Emanuela Bellu Serenella Medici Donatella Coradduzza Sara Cruciani Evzen Amler Margherita Maioli Nanomaterials in Skin Regeneration and Rejuvenation International Journal of Molecular Sciences nanomaterials stem cells cellular mechanisms skin regenerative medicine |
| title | Nanomaterials in Skin Regeneration and Rejuvenation |
| title_full | Nanomaterials in Skin Regeneration and Rejuvenation |
| title_fullStr | Nanomaterials in Skin Regeneration and Rejuvenation |
| title_full_unstemmed | Nanomaterials in Skin Regeneration and Rejuvenation |
| title_short | Nanomaterials in Skin Regeneration and Rejuvenation |
| title_sort | nanomaterials in skin regeneration and rejuvenation |
| topic | nanomaterials stem cells cellular mechanisms skin regenerative medicine |
| url | https://www.mdpi.com/1422-0067/22/13/7095 |
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