Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine
Cytarabine (Cyt) encapsulated calcium carbonate (CaCO3) nanospheres were facilely synthesized through a simple co-precipitation method, and the Cyt encapsulated CaCO3 nanospheres (CaCO3/Cyt) were modified by polyacrylic acid (PAA) hydrogels through in situ polymerization of acrylic acid (AA) monomer...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-11-01
|
| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610321001496 |
| _version_ | 1818929102862680064 |
|---|---|
| author | Lefeng Liu Zhiguo Xu Yang Liu Zheng-Zhi Yin Yanshan Sheng Chengqiang Ding Yong Kong |
| author_facet | Lefeng Liu Zhiguo Xu Yang Liu Zheng-Zhi Yin Yanshan Sheng Chengqiang Ding Yong Kong |
| author_sort | Lefeng Liu |
| collection | DOAJ |
| description | Cytarabine (Cyt) encapsulated calcium carbonate (CaCO3) nanospheres were facilely synthesized through a simple co-precipitation method, and the Cyt encapsulated CaCO3 nanospheres (CaCO3/Cyt) were modified by polyacrylic acid (PAA) hydrogels through in situ polymerization of acrylic acid (AA) monomer on the surface of the CaCO3/Cyt. Successful preparation of the Cyt loaded CaCO3/PAA hydrogels were confirmed by the characterization of SEM, TEM and FT-IR. Premature release of Cyt in acidic medium (pH = 1.2) could be effectively circumvented by the introduction of the PAA hydrogels. More importantly, pH-responsive delivery of Cyt from the as-prepared CaCO3/PAA hydrogels could be achieved due to the pH-sensitivity of the PAA. Although the highest swelling ratio of PAA was obtained at pH 7.3 (27.7), the highest cumulative release of Cyt from the carrier was achieved at pH 5.3 (86.75%), which might be attributed to the high stability of CaCO3 at pH 7.3. That is to say, the highest cumulative release of Cyt at pH 5.3 was a compromise by considering the relatively high swelling ratio of PAA and the relatively low stability of CaCO3. |
| first_indexed | 2024-12-20T03:39:28Z |
| format | Article |
| id | doaj.art-c1d5d0de25bd4393902436e7f7787ada |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-20T03:39:28Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-c1d5d0de25bd4393902436e7f7787ada2022-12-21T19:54:47ZengElsevierJournal of Saudi Chemical Society1319-61032021-11-012511101344Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabineLefeng Liu0Zhiguo Xu1Yang Liu2Zheng-Zhi Yin3Yanshan Sheng4Chengqiang Ding5Yong Kong6Xiehe Union East China Stem Cell & Gene Engineering Co., Ltd., Huzhou 313000, ChinaXiehe Union East China Stem Cell & Gene Engineering Co., Ltd., Huzhou 313000, ChinaXiehe Union East China Stem Cell & Gene Engineering Co., Ltd., Huzhou 313000, ChinaCollege of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China; Corresponding authors.Jiangsu Key Laboratory of Advanced Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, ChinaJiangsu Key Laboratory of Advanced Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, ChinaJiangsu Key Laboratory of Advanced Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China; Corresponding authors.Cytarabine (Cyt) encapsulated calcium carbonate (CaCO3) nanospheres were facilely synthesized through a simple co-precipitation method, and the Cyt encapsulated CaCO3 nanospheres (CaCO3/Cyt) were modified by polyacrylic acid (PAA) hydrogels through in situ polymerization of acrylic acid (AA) monomer on the surface of the CaCO3/Cyt. Successful preparation of the Cyt loaded CaCO3/PAA hydrogels were confirmed by the characterization of SEM, TEM and FT-IR. Premature release of Cyt in acidic medium (pH = 1.2) could be effectively circumvented by the introduction of the PAA hydrogels. More importantly, pH-responsive delivery of Cyt from the as-prepared CaCO3/PAA hydrogels could be achieved due to the pH-sensitivity of the PAA. Although the highest swelling ratio of PAA was obtained at pH 7.3 (27.7), the highest cumulative release of Cyt from the carrier was achieved at pH 5.3 (86.75%), which might be attributed to the high stability of CaCO3 at pH 7.3. That is to say, the highest cumulative release of Cyt at pH 5.3 was a compromise by considering the relatively high swelling ratio of PAA and the relatively low stability of CaCO3.http://www.sciencedirect.com/science/article/pii/S1319610321001496CaCO3 nanospheresPolyacrylic acidHydrogelspH-Responsive deliveryCytarabine |
| spellingShingle | Lefeng Liu Zhiguo Xu Yang Liu Zheng-Zhi Yin Yanshan Sheng Chengqiang Ding Yong Kong Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine Journal of Saudi Chemical Society CaCO3 nanospheres Polyacrylic acid Hydrogels pH-Responsive delivery Cytarabine |
| title | Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine |
| title_full | Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine |
| title_fullStr | Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine |
| title_full_unstemmed | Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine |
| title_short | Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine |
| title_sort | facile synthesis of calcium carbonate polyacrylic acid hydrogels for ph responsive delivery of cytarabine |
| topic | CaCO3 nanospheres Polyacrylic acid Hydrogels pH-Responsive delivery Cytarabine |
| url | http://www.sciencedirect.com/science/article/pii/S1319610321001496 |
| work_keys_str_mv | AT lefengliu facilesynthesisofcalciumcarbonatepolyacrylicacidhydrogelsforphresponsivedeliveryofcytarabine AT zhiguoxu facilesynthesisofcalciumcarbonatepolyacrylicacidhydrogelsforphresponsivedeliveryofcytarabine AT yangliu facilesynthesisofcalciumcarbonatepolyacrylicacidhydrogelsforphresponsivedeliveryofcytarabine AT zhengzhiyin facilesynthesisofcalciumcarbonatepolyacrylicacidhydrogelsforphresponsivedeliveryofcytarabine AT yanshansheng facilesynthesisofcalciumcarbonatepolyacrylicacidhydrogelsforphresponsivedeliveryofcytarabine AT chengqiangding facilesynthesisofcalciumcarbonatepolyacrylicacidhydrogelsforphresponsivedeliveryofcytarabine AT yongkong facilesynthesisofcalciumcarbonatepolyacrylicacidhydrogelsforphresponsivedeliveryofcytarabine |