Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies

Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies

Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its...

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Bibliographic Details
Main Authors: Janaina da Silva Goes, Fátima Duarte Freire, Túlio Flávio Accioly de Lima e Moura, Cícero Flávio Soares Aragão, Fernanda Nervo Raffin
Format: Article
Language:English
Published: Universidade de São Paulo 2019-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Pediatric Formulation
Captopril/ pharmacokinetics
Thermal Analysis
Degradation Kinetics
Drug Stability
Drug Compounding/ utilization
Drug Utilization
Excipients/ pharmacokinetics
Dosage Forms
Drug Dosage Calculations
Kinetics
Enzyme Stability/drug effects
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100603&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100603&tlng=en

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