Regulation of the mitochondrial permeability transition pore and its effects on aging
Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems. Among these, the budding yeast Saccharomyces cerevisiae has been reported multipl...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2020-06-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/2020a-pellegrino-coppola-microbial-cell/ |
| _version_ | 1826532059445723136 |
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| author | Damiano Pellegrino-Coppola |
| author_facet | Damiano Pellegrino-Coppola |
| author_sort | Damiano Pellegrino-Coppola |
| collection | DOAJ |
| description | Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems. Among these, the budding yeast Saccharomyces cerevisiae has been reported multiple times as a model of choice when studying cellular aging. In particular, yeast provides a quick and trustworthy system to identify shared aging genes and pathway patterns. In this viewpoint on aging and mitochondria, I will focus on the mitochondrial permeability transition pore (mPTP), which has been reported and proposed as a main player in cellular aging. I will make several parallelisms with yeast to highlight how this unicellular organism can be used as a guidance system to understand conserved cellular and molecular events in multicellular organisms such as humans. Overall, a thread connecting the preservation of mitochondrial functionality with the activity of the mPTP emerges in the regulation of cell survival and cell death, which in turn could potentially affect aging and aging-related diseases. |
| first_indexed | 2024-12-23T10:19:12Z |
| format | Article |
| id | doaj.art-c1d64d77b799429bb503c5de172efdb0 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2025-03-14T01:45:13Z |
| publishDate | 2020-06-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-c1d64d77b799429bb503c5de172efdb02025-03-12T13:46:43ZengShared Science Publishers OGMicrobial Cell2311-26382020-06-017922223310.15698/mic2020.09.728Regulation of the mitochondrial permeability transition pore and its effects on agingDamiano Pellegrino-Coppola0AI Lab One, Wilhelmina van Pruisenweg 35, 2595 AN The Hague, The Netherlands.Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems. Among these, the budding yeast Saccharomyces cerevisiae has been reported multiple times as a model of choice when studying cellular aging. In particular, yeast provides a quick and trustworthy system to identify shared aging genes and pathway patterns. In this viewpoint on aging and mitochondria, I will focus on the mitochondrial permeability transition pore (mPTP), which has been reported and proposed as a main player in cellular aging. I will make several parallelisms with yeast to highlight how this unicellular organism can be used as a guidance system to understand conserved cellular and molecular events in multicellular organisms such as humans. Overall, a thread connecting the preservation of mitochondrial functionality with the activity of the mPTP emerges in the regulation of cell survival and cell death, which in turn could potentially affect aging and aging-related diseases.http://microbialcell.com/researcharticles/2020a-pellegrino-coppola-microbial-cell/agingmitochondriayeastmptpcell death adenine nucleotide translocator |
| spellingShingle | Damiano Pellegrino-Coppola Regulation of the mitochondrial permeability transition pore and its effects on aging Microbial Cell aging mitochondria yeast mptp cell death adenine nucleotide translocator |
| title | Regulation of the mitochondrial permeability transition pore and its effects on aging |
| title_full | Regulation of the mitochondrial permeability transition pore and its effects on aging |
| title_fullStr | Regulation of the mitochondrial permeability transition pore and its effects on aging |
| title_full_unstemmed | Regulation of the mitochondrial permeability transition pore and its effects on aging |
| title_short | Regulation of the mitochondrial permeability transition pore and its effects on aging |
| title_sort | regulation of the mitochondrial permeability transition pore and its effects on aging |
| topic | aging mitochondria yeast mptp cell death adenine nucleotide translocator |
| url | http://microbialcell.com/researcharticles/2020a-pellegrino-coppola-microbial-cell/ |
| work_keys_str_mv | AT damianopellegrinocoppola regulationofthemitochondrialpermeabilitytransitionporeanditseffectsonaging |