Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children
Obesity is associated with the presence of low-grade inflammation even during childhood. The dysregulation in the secretion of adipokines, such as leptin, which occurs in obesity states, could be associated with an increase in inflammatory factors already at an early age. In this cross-sectional stu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/10/2388 |
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| author | Claudia Vales-Villamarín Olaya de Dios Iris Pérez-Nadador Teresa Gavela-Pérez Leandro Soriano-Guillén Carmen Garcés |
| author_facet | Claudia Vales-Villamarín Olaya de Dios Iris Pérez-Nadador Teresa Gavela-Pérez Leandro Soriano-Guillén Carmen Garcés |
| author_sort | Claudia Vales-Villamarín |
| collection | DOAJ |
| description | Obesity is associated with the presence of low-grade inflammation even during childhood. The dysregulation in the secretion of adipokines, such as leptin, which occurs in obesity states, could be associated with an increase in inflammatory factors already at an early age. In this cross-sectional study, we aimed to investigate the role of leptin levels in the association between body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) in healthy schoolchildren. Leptin and hs-CRP levels were analyzed in two pediatric cohorts comprising 684 prepubertal children and 763 adolescents. hs-CRP concentrations correlated significantly with BMI and leptin levels in prepubertal males and females as well as in adolescents. However, after adjusting for leptin concentration, no significant correlation was observed between hs-CRP and BMI in prepubertal children, while the correlations remained significant in adolescents. The same differences were observed when analyzed BMI according to hs-CRP tertile after adjusting for leptin; mean BMI was not significantly different between hs-CRP tertile in prepubertal children but was significantly different in adolescents. In conclusion, the fact that leptin concentrations determine the association of BMI with hs-CRP levels in prepubertal children, but not in adolescents, suggests a role for leptin in low-grade inflammation at early ages, while other factors seem to contribute to hs-CRP levels later in life. |
| first_indexed | 2024-03-11T03:25:47Z |
| format | Article |
| id | doaj.art-c1d6be773741471d95149634d415bbdb |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T03:25:47Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c1d6be773741471d95149634d415bbdb2023-11-18T02:45:42ZengMDPI AGNutrients2072-66432023-05-011510238810.3390/nu15102388Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal ChildrenClaudia Vales-Villamarín0Olaya de Dios1Iris Pérez-Nadador2Teresa Gavela-Pérez3Leandro Soriano-Guillén4Carmen Garcés5Lipid Research Laboratory, IIS-Fundación Jimenez Diaz, UAM, 28040 Madrid, SpainLipid Research Laboratory, IIS-Fundación Jimenez Diaz, UAM, 28040 Madrid, SpainLipid Research Laboratory, IIS-Fundación Jimenez Diaz, UAM, 28040 Madrid, SpainDepartment of Pediatrics, IIS-Fundación Jimenez Diaz, UAM, 28040 Madrid, SpainDepartment of Pediatrics, IIS-Fundación Jimenez Diaz, UAM, 28040 Madrid, SpainLipid Research Laboratory, IIS-Fundación Jimenez Diaz, UAM, 28040 Madrid, SpainObesity is associated with the presence of low-grade inflammation even during childhood. The dysregulation in the secretion of adipokines, such as leptin, which occurs in obesity states, could be associated with an increase in inflammatory factors already at an early age. In this cross-sectional study, we aimed to investigate the role of leptin levels in the association between body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) in healthy schoolchildren. Leptin and hs-CRP levels were analyzed in two pediatric cohorts comprising 684 prepubertal children and 763 adolescents. hs-CRP concentrations correlated significantly with BMI and leptin levels in prepubertal males and females as well as in adolescents. However, after adjusting for leptin concentration, no significant correlation was observed between hs-CRP and BMI in prepubertal children, while the correlations remained significant in adolescents. The same differences were observed when analyzed BMI according to hs-CRP tertile after adjusting for leptin; mean BMI was not significantly different between hs-CRP tertile in prepubertal children but was significantly different in adolescents. In conclusion, the fact that leptin concentrations determine the association of BMI with hs-CRP levels in prepubertal children, but not in adolescents, suggests a role for leptin in low-grade inflammation at early ages, while other factors seem to contribute to hs-CRP levels later in life.https://www.mdpi.com/2072-6643/15/10/2388childrenhs-CRPbody mass indexleptin |
| spellingShingle | Claudia Vales-Villamarín Olaya de Dios Iris Pérez-Nadador Teresa Gavela-Pérez Leandro Soriano-Guillén Carmen Garcés Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children Nutrients children hs-CRP body mass index leptin |
| title | Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children |
| title_full | Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children |
| title_fullStr | Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children |
| title_full_unstemmed | Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children |
| title_short | Leptin Concentrations Determine the Association between High-Sensitivity C-Reactive Protein Levels and Body Mass Index in Prepubertal Children |
| title_sort | leptin concentrations determine the association between high sensitivity c reactive protein levels and body mass index in prepubertal children |
| topic | children hs-CRP body mass index leptin |
| url | https://www.mdpi.com/2072-6643/15/10/2388 |
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