Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection
Abstract Background To investigate related factors for postoperative pathological upgrading of cervical biopsy to cervical cancer (CC) in patients with cervical intraepithelial neoplasia (CIN)3 after conical resection. Methods This retrospective study collected data from patients diagnosed with CIN3...
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BMC
2024-04-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-12186-w |
| _version_ | 1797219758260617216 |
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| author | Zhifang Li Guiju Zhou Longfan Jiang Mengjie Wang |
| author_facet | Zhifang Li Guiju Zhou Longfan Jiang Mengjie Wang |
| author_sort | Zhifang Li |
| collection | DOAJ |
| description | Abstract Background To investigate related factors for postoperative pathological upgrading of cervical biopsy to cervical cancer (CC) in patients with cervical intraepithelial neoplasia (CIN)3 after conical resection. Methods This retrospective study collected data from patients diagnosed with CIN3 by cervical biopsies at the author’s Hospital between January 2012 and December 2022. The primary outcome was the pathological results of patients after conical resection. The pathological findings were categorized into the pathological upgrading group if postoperative pathology indicated CC, while those with normal, inflammatory, or cervical precancerous lesions were classified into the pathological non-upgrading group. The factors associated with upgrading were identified using multivariable logistic regression analysis. Results Among 511 patients, there were 125 patients in the pathological upgrading group (24.46%). The patients in the upgrading group were younger (47.68 ± 9.46 vs. 52.11 ± 7.02, P < 0.001), showed a lower proportion of menopausal women (38.40% vs. 53.02%, P = 0.0111), a lower proportion of HSIL (40.00% vs. 57.77%, P = 0.001), a higher rate of HPV-16/18 positive (25.60% vs. 17.36%, P = 0.011), a higher rate of contact bleeding (54.40% vs. 21.50%, P < 0.001), lower HDL levels (1.31 ± 0.29 vs. 1.37 ± 0.34 mmol/L, P = 0.002), higher neutrophil counts (median, 3.50 vs. 3.10 × 109/L, P = 0.001), higher red blood cell counts (4.01 ± 0.43 vs. 3.97 ± 0.47 × 1012/L, P = 0.002), higher platelet counts (204.84 ± 61.24 vs. 187.06 ± 73.66 × 109/L, P = 0.012), and a smaller platelet volume (median, 11.50 vs. 11.90 fL, P = 0.002).The multivariable logistic regression analysis showed that age (OR = 0.90, 95% CI: 0.86–0.94, P < 0.001), menopausal (OR = 2.68, 95% CI: 1.38–5.22, P = 0.004), contact bleeding (OR = 4.80, 95% CI: 2.91–7.91, P < 0.001), and mean platelet volume (OR = 0.83, 95% CI: 0.69–0.99, P = 0.038) were independently associated with pathological upgrading from CIN3 to CC after conical resection. Conclusion Age, menopausal, contact bleeding, and mean platelet volume are risk factors of pathological upgrading from CIN3 to CC after conical resection, which could help identify high risk and susceptible patients of pathological upgrading to CC. |
| first_indexed | 2024-04-24T12:38:44Z |
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| language | English |
| last_indexed | 2024-04-24T12:38:44Z |
| publishDate | 2024-04-01 |
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| spelling | doaj.art-c1d7540f315f4a748bd0c21f40bba89a2024-04-07T11:21:23ZengBMCBMC Cancer1471-24072024-04-012411610.1186/s12885-024-12186-wAnalysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resectionZhifang Li0Guiju Zhou1Longfan Jiang2Mengjie Wang3Department of Gynaecology, Anqing Municipal Hospital, Anhui Medical UniversityThe Second Affiliated Hospital of Anhui Medical UniversityDepartment of Gynaecology, Anqing Municipal Hospital, Anhui Medical UniversityDepartment of Gynaecology, Anqing Municipal Hospital, Anhui Medical UniversityAbstract Background To investigate related factors for postoperative pathological upgrading of cervical biopsy to cervical cancer (CC) in patients with cervical intraepithelial neoplasia (CIN)3 after conical resection. Methods This retrospective study collected data from patients diagnosed with CIN3 by cervical biopsies at the author’s Hospital between January 2012 and December 2022. The primary outcome was the pathological results of patients after conical resection. The pathological findings were categorized into the pathological upgrading group if postoperative pathology indicated CC, while those with normal, inflammatory, or cervical precancerous lesions were classified into the pathological non-upgrading group. The factors associated with upgrading were identified using multivariable logistic regression analysis. Results Among 511 patients, there were 125 patients in the pathological upgrading group (24.46%). The patients in the upgrading group were younger (47.68 ± 9.46 vs. 52.11 ± 7.02, P < 0.001), showed a lower proportion of menopausal women (38.40% vs. 53.02%, P = 0.0111), a lower proportion of HSIL (40.00% vs. 57.77%, P = 0.001), a higher rate of HPV-16/18 positive (25.60% vs. 17.36%, P = 0.011), a higher rate of contact bleeding (54.40% vs. 21.50%, P < 0.001), lower HDL levels (1.31 ± 0.29 vs. 1.37 ± 0.34 mmol/L, P = 0.002), higher neutrophil counts (median, 3.50 vs. 3.10 × 109/L, P = 0.001), higher red blood cell counts (4.01 ± 0.43 vs. 3.97 ± 0.47 × 1012/L, P = 0.002), higher platelet counts (204.84 ± 61.24 vs. 187.06 ± 73.66 × 109/L, P = 0.012), and a smaller platelet volume (median, 11.50 vs. 11.90 fL, P = 0.002).The multivariable logistic regression analysis showed that age (OR = 0.90, 95% CI: 0.86–0.94, P < 0.001), menopausal (OR = 2.68, 95% CI: 1.38–5.22, P = 0.004), contact bleeding (OR = 4.80, 95% CI: 2.91–7.91, P < 0.001), and mean platelet volume (OR = 0.83, 95% CI: 0.69–0.99, P = 0.038) were independently associated with pathological upgrading from CIN3 to CC after conical resection. Conclusion Age, menopausal, contact bleeding, and mean platelet volume are risk factors of pathological upgrading from CIN3 to CC after conical resection, which could help identify high risk and susceptible patients of pathological upgrading to CC.https://doi.org/10.1186/s12885-024-12186-wCervical intraepithelial neoplasiaBiopsyUterine cervical neoplasmsPathological upgradingRisk factors |
| spellingShingle | Zhifang Li Guiju Zhou Longfan Jiang Mengjie Wang Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection BMC Cancer Cervical intraepithelial neoplasia Biopsy Uterine cervical neoplasms Pathological upgrading Risk factors |
| title | Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection |
| title_full | Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection |
| title_fullStr | Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection |
| title_full_unstemmed | Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection |
| title_short | Analysis of related factors for pathological upgrading of cervical biopsy from CIN3 to cancer after conical resection |
| title_sort | analysis of related factors for pathological upgrading of cervical biopsy from cin3 to cancer after conical resection |
| topic | Cervical intraepithelial neoplasia Biopsy Uterine cervical neoplasms Pathological upgrading Risk factors |
| url | https://doi.org/10.1186/s12885-024-12186-w |
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